{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rakesh M"],"funding":["Natural Sciences and Engineering Research Council of Canada","Canada Foundation for Innovation","CIHR"],"pagination":["btad136"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10049784"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["39(3)"],"pubmed_abstract":["<h4>Summary</h4>Founder populations with deep genealogical data are well suited for investigating genetic variants contributing to diseases. Here, we present a major update of the genealogical analysis R package GENLIB, centered around a new function which can simulate the transmission of haplotypes from founders to probands along very large and complex user-specified genealogies.<h4>Availability and implementation</h4>The latest update of the GENLIB package (v1.1.9) contains the new gen.simuHaplo() function and is available on the CRAN repository and from https://github.com/R-GENLIB/GENLIB. Examples can be accessed at https://github.com/R-GENLIB/simuhaplo_functions."],"journal":["Bioinformatics (Oxford, England)"],"pubmed_title":["GENLIB: new function to simulate haplotype transmission in large complex genealogies."],"pmcid":["PMC10049784"],"funding_grant_id":["MOP 133560"],"pubmed_authors":["Rakesh M","Laprise C","Freeman EE","Roy-Gagnon MH","Vezina H","Burkett KM"],"additional_accession":[]},"is_claimable":false,"name":"GENLIB: new function to simulate haplotype transmission in large complex genealogies.","description":"<h4>Summary</h4>Founder populations with deep genealogical data are well suited for investigating genetic variants contributing to diseases. Here, we present a major update of the genealogical analysis R package GENLIB, centered around a new function which can simulate the transmission of haplotypes from founders to probands along very large and complex user-specified genealogies.<h4>Availability and implementation</h4>The latest update of the GENLIB package (v1.1.9) contains the new gen.simuHaplo() function and is available on the CRAN repository and from https://github.com/R-GENLIB/GENLIB. Examples can be accessed at https://github.com/R-GENLIB/simuhaplo_functions.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-04-26T09:43:56.692Z","creation":"2024-11-09T02:39:45.104Z"},"accession":"S-EPMC10049784","cross_references":{"pubmed":["36929931"],"doi":["10.1093/bioinformatics/btad136"]}}