biostudies-literatureRakesh MNatural Sciences and Engineering Research Council of CanadaCanada Foundation for InnovationCIHRbtad136https://www.ebi.ac.uk/biostudies/studies/S-EPMC10049784biostudies-literatureUnknown39(3)<h4>Summary</h4>Founder populations with deep genealogical data are well suited for investigating genetic variants contributing to diseases. Here, we present a major update of the genealogical analysis R package GENLIB, centered around a new function which can simulate the transmission of haplotypes from founders to probands along very large and complex user-specified genealogies.<h4>Availability and implementation</h4>The latest update of the GENLIB package (v1.1.9) contains the new gen.simuHaplo() function and is available on the CRAN repository and from https://github.com/R-GENLIB/GENLIB. Examples can be accessed at https://github.com/R-GENLIB/simuhaplo_functions.Bioinformatics (Oxford, England)GENLIB: new function to simulate haplotype transmission in large complex genealogies.PMC10049784MOP 133560Rakesh MLaprise CFreeman EERoy-Gagnon MHVezina HBurkett KMfalseGENLIB: new function to simulate haplotype transmission in large complex genealogies.<h4>Summary</h4>Founder populations with deep genealogical data are well suited for investigating genetic variants contributing to diseases. Here, we present a major update of the genealogical analysis R package GENLIB, centered around a new function which can simulate the transmission of haplotypes from founders to probands along very large and complex user-specified genealogies.<h4>Availability and implementation</h4>The latest update of the GENLIB package (v1.1.9) contains the new gen.simuHaplo() function and is available on the CRAN repository and from https://github.com/R-GENLIB/GENLIB. Examples can be accessed at https://github.com/R-GENLIB/simuhaplo_functions.2023-01-01T00:00:00Z2023 Mar2025-04-26T09:43:56.692Z2024-11-09T02:39:45.104ZS-EPMC100497843692993110.1093/bioinformatics/btad136