{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(3)"],"submitter":["Giannini A"],"pubmed_abstract":["The objective of this work is to assess the 5-year outcomes of patients undergoing conization for high-grade cervical lesions that simultaneously present as risk factors in the persistence of HPV infection and the positivity of surgical resection margins. This is a retrospective study evaluating patients undergoing conization for high-grade cervical lesions. All patients included had both positive surgical margins and experienced HPV persistence at 6 months. Associations were evaluated with Cox proportional hazard regression and summarized using hazard ratio (HR). The charts of 2966 patients undergoing conization were reviewed. Among the whole population, 163 (5.5%) patients met the inclusion criteria, being at high risk due to the presence of positive surgical margins and experiencing HPV"],"journal":["Vaccines"],"pagination":["698"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10051663"],"repository":["biostudies-literature"],"pubmed_title":["Outcomes of High-Grade Cervical Dysplasia with Positive Margins and HPV Persistence after Cervical Conization."],"pmcid":["PMC10051663"],"pubmed_authors":["Borghi C","D'Ippolito G","Ciavattini A","Sarpietro G","Aguzzoli L","Bogani G","Simoncini T","Sopracordevole F","Ruisi S","Raspagliesi F","Casarin J","Dell'Acqua A","Malzoni M","Benedetti Panici P","Scambia G","Capobianco G","Pinelli C","Salerno MG","Giannini A","Contino B","Vercellini P","Perrone AM","Carlea A","Cianci A","Cuccu I","Ditto A","Palomba S","Monti E","Muschiato B","Greggi S","Ferrandina G","Muzii L","Donfrancesco C","Spinillo A","Bosio S","Bergamini A","Colacurci N","Giannella L","D'Oria O","Dario Mandato V","Liberale V","Zannoni GF","Ghezzi F","Golia D'Auge T","De Iaco P","Falcone F","Cianci S","Gardella B","De Vincenzo R","Mosca L","Desiato M","Matarazzo MG","Plotti F","Ghelardi A","Zullo F","Vizza E","Scaffa C","Serati M","Angioli R","Tinelli R","Petrillo M","Ferrero S","Di Giovanni A","Di Donato V"],"additional_accession":[]},"is_claimable":false,"name":"Outcomes of High-Grade Cervical Dysplasia with Positive Margins and HPV Persistence after Cervical Conization.","description":"The objective of this work is to assess the 5-year outcomes of patients undergoing conization for high-grade cervical lesions that simultaneously present as risk factors in the persistence of HPV infection and the positivity of surgical resection margins. This is a retrospective study evaluating patients undergoing conization for high-grade cervical lesions. All patients included had both positive surgical margins and experienced HPV persistence at 6 months. Associations were evaluated with Cox proportional hazard regression and summarized using hazard ratio (HR). The charts of 2966 patients undergoing conization were reviewed. Among the whole population, 163 (5.5%) patients met the inclusion criteria, being at high risk due to the presence of positive surgical margins and experiencing HPV","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-04-22T18:18:05.429Z","creation":"2025-02-19T00:14:28.206Z"},"accession":"S-EPMC10051663","cross_references":{"pubmed":["36992282"],"doi":["10.3390/vaccines11030698"]}}