{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cai JP"],"funding":["Richard Yu and Carol Yu, Michael Seak-Kan Tong, May Tam Mak Mei Yin, the Lee Wan Keung Charity Foundation Limited","Emergency COVID-19 Project","Chan Yin Chuen Memorial Charitable Foundation","Kai Chong Tong, Tse Kam Ming Laurence, the Foo Oi Foundation Limited","Major Science and Technology Program of Hainan Province","Perfect Shape Medical Limited","research project of Hainan Academician Innovation Platform","Hui Ming, Hui Hoy and the Chow Sin Lan Charity Fund Limited","Research Grants Council of the Hong Kong Special Administrative Region","Health and Medical Research Fund","Collaborative Research Fund","Hong Kong Sanatorium and Hospital","Marina Man-Wai Lee, the Hong Kong Hainan Commercial Association South China Microbiology Research Fund","Hainan Talent Development Project","Chen Wai Wai Vivien Foundation Limited","Providence Foundation Limited","Shaw Foundation Hong Kong","Emergency Collaborative Project of Guangzhou Laboratory","Betty Hing-Chu Lee, Ping Cham So, and the Lo Ying Shek Chi Wai Foundation","Jessie and George Ho Charitable Foundation","Health@InnoHK"],"pagination":["687"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10052291"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(3)"],"pubmed_abstract":["The emergence of new immune-evasive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and subvariants outpaces the development of vaccines specific against the dominant circulating strains. In terms of the only accepted immune correlate of protection, the inactivated whole-virion vaccine using wild-type SARS-CoV-2 spike induces a much lower serum neutralizing antibody titre against the Omicron subvariants. Since the inactivated vaccine given intramuscularly is one of the most commonly used coronavirus disease 2019 (COVID-19) vaccines in developing regions, we tested the hypothesis that intranasal boosting after intramuscular priming would provide a broader level of protection. Here, we showed that one or two intranasal boosts with the Fc-linked trimeric spike receptor-b"],"journal":["Viruses"],"pubmed_title":["Intranasal Boosting with Spike Fc-RBD of Wild-Type SARS-CoV-2 Induces Neutralizing Antibodies against Omicron Subvariants and Reduces Viral Load in the Nasal Turbinate of Mice."],"pmcid":["PMC10052291"],"funding_grant_id":["YSPTZX202004","C7060-21G","2021YFC0866100","ZDKJ202003","SRC200003","T11-709/21-N","COVID1903010–Projects 7","EKPG22-01"],"pubmed_authors":["Cai JP","Yuan S","Cao H","Jin DY","Zhang AJ","Chan JF","Chen LL","Han Y","Chen H","Luo C","Wang K","Yin F","Chen Z","Zhang X","To KK","Chu H","Yuen KY","Kok KH"],"additional_accession":[]},"is_claimable":false,"name":"Intranasal Boosting with Spike Fc-RBD of Wild-Type SARS-CoV-2 Induces Neutralizing Antibodies against Omicron Subvariants and Reduces Viral Load in the Nasal Turbinate of Mice.","description":"The emergence of new immune-evasive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and subvariants outpaces the development of vaccines specific against the dominant circulating strains. In terms of the only accepted immune correlate of protection, the inactivated whole-virion vaccine using wild-type SARS-CoV-2 spike induces a much lower serum neutralizing antibody titre against the Omicron subvariants. Since the inactivated vaccine given intramuscularly is one of the most commonly used coronavirus disease 2019 (COVID-19) vaccines in developing regions, we tested the hypothesis that intranasal boosting after intramuscular priming would provide a broader level of protection. Here, we showed that one or two intranasal boosts with the Fc-linked trimeric spike receptor-b","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2026-05-14T03:09:20.052Z","creation":"2024-11-05T18:16:18.934Z"},"accession":"S-EPMC10052291","cross_references":{"pubmed":["36992395"],"doi":["10.3390/v15030687"]}}