biostudies-literatureUnknown10(2)Radhoe SP<h4>Aims</h4>Data on sex and left ventricular assist device (LVAD) utilization and outcomes have been conflicting and mostly confined to US studies incorporating older devices. This study aimed to investigate sex-related differences in LVAD utilization and outcomes in a contemporary European LVAD cohort.<h4>Methods and results</h4>This analysis is part of the multicentre PCHF-VAD registry studying continuous-flow LVAD patients. The primary outcome was all-cause mortality. Secondary outcomes included ventricular arrhythmias, right ventricular failure, bleeding, thromboembolism, and the haemocompatibility score. Multivariable Cox regression models were used to assess associations between sex and outcomes. Overall, 457 men (81%) and 105 women (19%) were analysed. At LVAD implant, women were mESC heart failure1054-1065https://www.ebi.ac.uk/biostudies/studies/S-EPMC10053365biostudies-literatureSex-related differences in left ventricular assist device utilization and outcomes: results from the PCHF-VAD registry.PMC10053365Brugts JJCikes MRubis PGkouziouta AHolcman KWierzbicki KD'Amario DMacek JLBraun OOTimmermans PGaizauskas EPlaninc IFlammer AJRuschitzka FDroogne WRadhoe SPBiocina BPouleur ACMeyns BVeenis JFLund LHGrundmann SMilicic DJakus NVan Craenenbroeck EMPaolillo SGasparovic HBarge-Caballero EfalseSex-related differences in left ventricular assist device utilization and outcomes: results from the PCHF-VAD registry.<h4>Aims</h4>Data on sex and left ventricular assist device (LVAD) utilization and outcomes have been conflicting and mostly confined to US studies incorporating older devices. This study aimed to investigate sex-related differences in LVAD utilization and outcomes in a contemporary European LVAD cohort.<h4>Methods and results</h4>This analysis is part of the multicentre PCHF-VAD registry studying continuous-flow LVAD patients. The primary outcome was all-cause mortality. Secondary outcomes included ventricular arrhythmias, right ventricular failure, bleeding, thromboembolism, and the haemocompatibility score. Multivariable Cox regression models were used to assess associations between sex and outcomes. Overall, 457 men (81%) and 105 women (19%) were analysed. At LVAD implant, women were m2023-01-01T00:00:00Z2023 Apr2026-07-14T19:03:30.576Z2025-02-19T01:13:39.584ZS-EPMC100533653654701410.1002/ehf2.14261