{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(3)"],"submitter":["Sakyi PO"],"pubmed_abstract":["The recent outlook of leishmaniasis as a global public health concern coupled with the reportage of resistance and lack of efficacy of most antileishmanial drugs calls for a concerted effort to find new leads. The study combined <i>In silico</i> and in vitro approaches to identify novel potential synthetic small-molecule inhibitors targeting the <i>Leishmania donovani</i> sterol methyltransferase (<i>Ld</i>SMT). The <i>Ld</i>SMT enzyme in the ergosterol biosynthetic pathway is required for the parasite's membrane fluidity, distribution of membrane proteins, and control of the cell cycle. The lack of <i>Ld</i>SMT homologue in the human host and its conserved nature among all <i>Leishmania</i> parasites makes it a viable target for future antileishmanial drugs. Initially, six known inhibitor"],"journal":["Pharmaceuticals (Basel, Switzerland)"],"pagination":["330"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10054574"],"repository":["biostudies-literature"],"pubmed_title":["Inhibiting <i>Leishmania donovani</i> Sterol Methyltransferase to Identify Lead Compounds Using Molecular Modelling."],"pmcid":["PMC10054574"],"pubmed_authors":["Miller WA","Wilson MD","Tuekpe JK","Kwofie SK","Gwira TM","Broni E","Amewu RK","Sakyi PO"],"additional_accession":[]},"is_claimable":false,"name":"Inhibiting <i>Leishmania donovani</i> Sterol Methyltransferase to Identify Lead Compounds Using Molecular Modelling.","description":"The recent outlook of leishmaniasis as a global public health concern coupled with the reportage of resistance and lack of efficacy of most antileishmanial drugs calls for a concerted effort to find new leads. The study combined <i>In silico</i> and in vitro approaches to identify novel potential synthetic small-molecule inhibitors targeting the <i>Leishmania donovani</i> sterol methyltransferase (<i>Ld</i>SMT). The <i>Ld</i>SMT enzyme in the ergosterol biosynthetic pathway is required for the parasite's membrane fluidity, distribution of membrane proteins, and control of the cell cycle. The lack of <i>Ld</i>SMT homologue in the human host and its conserved nature among all <i>Leishmania</i> parasites makes it a viable target for future antileishmanial drugs. Initially, six known inhibitor","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-22T18:22:10.011Z","creation":"2025-02-19T01:13:26.982Z"},"accession":"S-EPMC10054574","cross_references":{"pubmed":["36986430"],"doi":["10.3390/ph16030330"]}}