{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Khan MM"],"funding":["NCATS NIH HHS","NIDCR NIH HHS","NIAID NIH HHS","NCI NIH HHS","NIGMS NIH HHS"],"pubmed_abstract":["Head and neck cancers are a complex malignancy comprising multiple anatomical sites, with cancer of the oral cavity ranking among the deadliest and most disfiguring cancers globally. Oral cancer (OC) constitutes a subset of head and neck cancer cases, presenting primarily as tobacco-and alcohol-associated oral squamous cell carcinoma (OSCC), with a 5-year survival rate of ∼65%, partly due to the lack of early detection and effective treatments. OSCC arises from premalignant lesions (PMLs) in the oral cavity through a multi-step series of clinical and histopathological stages, including varying degrees of epithelial dysplasia. To gain insights into the molecular mechanisms associated with the progression of PMLs to OSCC, we profiled the whole transcriptome of 66 human PMLs comprising leuk"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2023.03.24.534064"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10055367"],"repository":["biostudies-literature"],"pubmed_title":["Total RNA sequencing reveals gene expression and microbial alterations shared by oral pre-malignant lesions and cancer."],"pmcid":["PMC10055367"],"funding_grant_id":["UL1 TR001430","R01 DE031831","R21 CA260382","R21 AI154387","R01 GM127430","R01 DE030350"],"pubmed_authors":["Khan MM","Nguyen BC","Villa A","Varelas X","Kukuruzinska M","Monti S","Frustino J","Woo SB","Johnson WE"],"additional_accession":[]},"is_claimable":false,"name":"Total RNA sequencing reveals gene expression and microbial alterations shared by oral pre-malignant lesions and cancer.","description":"Head and neck cancers are a complex malignancy comprising multiple anatomical sites, with cancer of the oral cavity ranking among the deadliest and most disfiguring cancers globally. Oral cancer (OC) constitutes a subset of head and neck cancer cases, presenting primarily as tobacco-and alcohol-associated oral squamous cell carcinoma (OSCC), with a 5-year survival rate of ∼65%, partly due to the lack of early detection and effective treatments. OSCC arises from premalignant lesions (PMLs) in the oral cavity through a multi-step series of clinical and histopathological stages, including varying degrees of epithelial dysplasia. To gain insights into the molecular mechanisms associated with the progression of PMLs to OSCC, we profiled the whole transcriptome of 66 human PMLs comprising leuk","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2026-04-08T13:24:58.611Z","creation":"2025-02-19T04:46:06.843Z"},"accession":"S-EPMC10055367","cross_references":{"pubmed":["36993637"],"doi":["10.1101/2023.03.24.534064"]}}