{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(13)"],"submitter":["Zheng X"],"pubmed_abstract":["The photosensitizers (PSs) for photodynamic therapy (PDT) mostly possess conjugated skeletons that are over-sized and poorly water-soluble to be encapsulated by conventional macrocyclic receptors. Herein, we report that two fluorescent hydrophilic cyclophanes, AnBox·4Cl and ExAnBox·4Cl, can effectively bind hypocrellin B (HB), a pharmaceutically active natural PS for PDT, with binding constants of the 107 level in aqueous solutions. The two macrocycles feature extended electron-deficient cavities and can be facilely synthesized through photo-induced ring expansions. The corresponding supramolecular PSs (HB⊂AnBox4+ and HB⊂ExAnBox4+) exhibit desirable stability, biocompatibility, and cellular delivery, as well as excellent PDT efficiency against cancer cells. In addition, living cell imaging"],"journal":["Chemical science"],"pagination":["3523-3530"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10055832"],"repository":["biostudies-literature"],"pubmed_title":["Supramolecular photosensitizers using extended macrocyclic hosts for photodynamic therapy with distinct cellular delivery† † Electronic supplementary information (ESI) available: General information, synthesis and characterization, host–guest chemistry, photodynamic therapy related cell experiments, and DFT calculations. See DOI: https://doi.org/10.1039/d3sc00107e"],"pmcid":["PMC10055832"],"pubmed_authors":["Zheng X","Wu L","Wang P","Dong X","Tung C","Xiao H","Gao Z","Cong H","Lei S","Liu W"],"additional_accession":[]},"is_claimable":false,"name":"Supramolecular photosensitizers using extended macrocyclic hosts for photodynamic therapy with distinct cellular delivery† † Electronic supplementary information (ESI) available: General information, synthesis and characterization, host–guest chemistry, photodynamic therapy related cell experiments, and DFT calculations. See DOI: https://doi.org/10.1039/d3sc00107e","description":"The photosensitizers (PSs) for photodynamic therapy (PDT) mostly possess conjugated skeletons that are over-sized and poorly water-soluble to be encapsulated by conventional macrocyclic receptors. Herein, we report that two fluorescent hydrophilic cyclophanes, AnBox·4Cl and ExAnBox·4Cl, can effectively bind hypocrellin B (HB), a pharmaceutically active natural PS for PDT, with binding constants of the 107 level in aqueous solutions. The two macrocycles feature extended electron-deficient cavities and can be facilely synthesized through photo-induced ring expansions. The corresponding supramolecular PSs (HB⊂AnBox4+ and HB⊂ExAnBox4+) exhibit desirable stability, biocompatibility, and cellular delivery, as well as excellent PDT efficiency against cancer cells. In addition, living cell imaging","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-04-04T14:50:57.342Z","creation":"2024-11-13T07:14:33.981Z"},"accession":"S-EPMC10055832","cross_references":{}}