biostudies-literatureZhao YNational Natural Science Foundation of China2537https://www.ebi.ac.uk/biostudies/studies/S-EPMC10059262biostudies-literatureUnknown28(6)Reported here is the synthesis of a macrocycle with equatorial coordination sites for the construction of self-assembled metallacages. The macrocycle is prepared <i>via</i> a post-modification on the equator of biphen[<i>n</i>]arene. Utilizing this macrocycle as a ligand, three prismatic cages and one octahedral cage were synthesized by regulating the geometric structures and coordination number of metal acceptors. The multi-cavity configuration of prismatic cage was revealed by single-crystal structure. We prove that a macrocycle with equatorial coordination sites can be an excellent building block for synthesizing structure-diverse metallacages. Our results provide a typical example and a general method for the design and synthesis of metallacages.Molecules (Basel, Switzerland)Macrocycle with Equatorial Coordination Sites Provides New Opportunity for Structure-Diverse Metallacages.PMC1005926221971192, 21772118, 21871208,22011530163Li CLu YZhang ZYLiu AZhao YSue ACfalseMacrocycle with Equatorial Coordination Sites Provides New Opportunity for Structure-Diverse Metallacages.Reported here is the synthesis of a macrocycle with equatorial coordination sites for the construction of self-assembled metallacages. The macrocycle is prepared <i>via</i> a post-modification on the equator of biphen[<i>n</i>]arene. Utilizing this macrocycle as a ligand, three prismatic cages and one octahedral cage were synthesized by regulating the geometric structures and coordination number of metal acceptors. The multi-cavity configuration of prismatic cage was revealed by single-crystal structure. We prove that a macrocycle with equatorial coordination sites can be an excellent building block for synthesizing structure-diverse metallacages. Our results provide a typical example and a general method for the design and synthesis of metallacages.2023-01-01T00:00:00Z2023 Mar2025-04-22T18:16:24.024Z2025-02-19T01:12:54.635ZS-EPMC100592623698550810.3390/molecules28062537