biostudies-literatureUnknown55(4)Ishikawa H<h4>Background</h4>Total colectomy is the standard treatment for familial adenomatous polyposis (FAP). Recently, an increasing number of young patients with FAP have requested the postponement of surgery or have refused to undergo surgery. We aimed to evaluate the effectiveness of intensive endoscopic removal for downstaging of polyp burden (IDP) in FAP.<h4>Method</h4>A single-arm intervention study was conducted at 22 facilities. Participants were patients with FAP, aged ≥ 16 years, who had not undergone colectomy or who had undergone colectomy but had ≥ 10 cm of large intestine remaining. For IDP, colorectal polyps of ≥ 10 mm were removed, followed by polyps of ≥ 5 mm. The primary end point was the presence/absence of colectomy during a 5-year intervention period.<h4>Results</h4>222 patiEndoscopy344-352https://www.ebi.ac.uk/biostudies/studies/S-EPMC10060053biostudies-literatureIntensive endoscopic resection for downstaging of polyp burden in patients with familial adenomatous polyposis (J-FAPP Study III): a multicenter prospective interventional study.PMC10060053Suzuki SSano YTashiro JDoyama HLee KKiriyama SSato YKobayashi NMutoh MSaida YJ-FAPP Study III GroupTanaka STakayama TOhda YKashida HIshida HAkiko CTanakaya KTakeuchi YYamada MIshikawa HIkematsu HTajika MNakajima THorimatsu THori SfalseIntensive endoscopic resection for downstaging of polyp burden in patients with familial adenomatous polyposis (J-FAPP Study III): a multicenter prospective interventional study.<h4>Background</h4>Total colectomy is the standard treatment for familial adenomatous polyposis (FAP). Recently, an increasing number of young patients with FAP have requested the postponement of surgery or have refused to undergo surgery. We aimed to evaluate the effectiveness of intensive endoscopic removal for downstaging of polyp burden (IDP) in FAP.<h4>Method</h4>A single-arm intervention study was conducted at 22 facilities. Participants were patients with FAP, aged ≥ 16 years, who had not undergone colectomy or who had undergone colectomy but had ≥ 10 cm of large intestine remaining. For IDP, colorectal polyps of ≥ 10 mm were removed, followed by polyps of ≥ 5 mm. The primary end point was the presence/absence of colectomy during a 5-year intervention period.<h4>Results</h4>222 pati2023-01-01T00:00:00Z2023 Apr2025-04-22T18:14:55.339Z2025-02-19T01:12:45.812ZS-EPMC100600533621626610.1055/a-1945-9120