{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bustos BI"],"funding":["National Institute of Neurological Disorders and Stroke","National Institute of Environmental Health Sciences","Intramural NIH HHS","NIA NIH HHS","Simpson Querrey Center for Neurogenetics","Department of Health and Human Services","Intramural Research Programs of the National Institute of Neurological Disorders and Stroke","National Institute of Environmental Health Sciences,","National Institutes of Health","Department of Defense","National Institute on Aging","Michael J Fox Foundation for Parkinson's Research","NIH HHS","Michael J Fox Foundation for Parkinson’s Research"],"pagination":["65-74"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10060720"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["146(1)"],"pubmed_abstract":["Parkinson's disease is a complex neurodegenerative disorder with a strong genetic component, for which most known disease-associated variants are single nucleotide polymorphisms (SNPs) and small insertions and deletions (indels). DNA repetitive elements account for >50% of the human genome; however, little is known of their contribution to Parkinson's disease aetiology. While select short tandem repeats (STRs) within candidate genes have been studied in Parkinson's disease, their genome-wide contribution remains unknown. Here we present the first genome-wide association study of STRs in Parkinson's disease. Through a meta-analysis of 16 imputed genome-wide association study cohorts from the International Parkinson's Disease Genomic Consortium (IPDGC), totalling 39 087 individuals (16 642 c"],"journal":["Brain : a journal of neurology"],"pubmed_title":["Genome-wide contribution of common short-tandem repeats to Parkinson's disease genetic risk."],"pmcid":["PMC10060720"],"funding_grant_id":["Z01-AG000949-02","Z01 AG000949","Z01 ES101986","1ZIA-NS003154","Z01-ES101986","W81XWH-09-2-0128"],"pubmed_authors":["Gibbs JR","Bustos BI","Gan-Or Z","Singleton AB","Krainc D","Lubbe SJ","Billingsley K","Blauwendraat C","International Parkinson’s Disease Genomics Consortium (IPDGC)"],"additional_accession":[]},"is_claimable":false,"name":"Genome-wide contribution of common short-tandem repeats to Parkinson's disease genetic risk.","description":"Parkinson's disease is a complex neurodegenerative disorder with a strong genetic component, for which most known disease-associated variants are single nucleotide polymorphisms (SNPs) and small insertions and deletions (indels). DNA repetitive elements account for >50% of the human genome; however, little is known of their contribution to Parkinson's disease aetiology. While select short tandem repeats (STRs) within candidate genes have been studied in Parkinson's disease, their genome-wide contribution remains unknown. Here we present the first genome-wide association study of STRs in Parkinson's disease. Through a meta-analysis of 16 imputed genome-wide association study cohorts from the International Parkinson's Disease Genomic Consortium (IPDGC), totalling 39 087 individuals (16 642 c","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-05-15T03:20:26.989Z","creation":"2025-02-19T02:23:29.029Z"},"accession":"S-EPMC10060720","cross_references":{"pubmed":["36347471"],"doi":["10.1093/brain/awac301"]}}