biostudies-literatureBustos BINational Institute of Neurological Disorders and StrokeNational Institute of Environmental Health SciencesIntramural NIH HHSNIA NIH HHSSimpson Querrey Center for NeurogeneticsDepartment of Health and Human ServicesIntramural Research Programs of the National Institute of Neurological Disorders and StrokeNational Institute of Environmental Health Sciences,National Institutes of HealthDepartment of DefenseNational Institute on AgingMichael J Fox Foundation for Parkinson's ResearchNIH HHSMichael J Fox Foundation for Parkinson’s Research65-74https://www.ebi.ac.uk/biostudies/studies/S-EPMC10060720biostudies-literatureUnknown146(1)Parkinson's disease is a complex neurodegenerative disorder with a strong genetic component, for which most known disease-associated variants are single nucleotide polymorphisms (SNPs) and small insertions and deletions (indels). DNA repetitive elements account for >50% of the human genome; however, little is known of their contribution to Parkinson's disease aetiology. While select short tandem repeats (STRs) within candidate genes have been studied in Parkinson's disease, their genome-wide contribution remains unknown. Here we present the first genome-wide association study of STRs in Parkinson's disease. Through a meta-analysis of 16 imputed genome-wide association study cohorts from the International Parkinson's Disease Genomic Consortium (IPDGC), totalling 39 087 individuals (16 642 cBrain : a journal of neurologyGenome-wide contribution of common short-tandem repeats to Parkinson's disease genetic risk.PMC10060720Z01-AG000949-02Z01 AG000949Z01 ES1019861ZIA-NS003154Z01-ES101986W81XWH-09-2-0128Gibbs JRBustos BIGan-Or ZSingleton ABKrainc DLubbe SJBillingsley KBlauwendraat CInternational Parkinson’s Disease Genomics Consortium (IPDGC)falseGenome-wide contribution of common short-tandem repeats to Parkinson's disease genetic risk.Parkinson's disease is a complex neurodegenerative disorder with a strong genetic component, for which most known disease-associated variants are single nucleotide polymorphisms (SNPs) and small insertions and deletions (indels). DNA repetitive elements account for >50% of the human genome; however, little is known of their contribution to Parkinson's disease aetiology. While select short tandem repeats (STRs) within candidate genes have been studied in Parkinson's disease, their genome-wide contribution remains unknown. Here we present the first genome-wide association study of STRs in Parkinson's disease. Through a meta-analysis of 16 imputed genome-wide association study cohorts from the International Parkinson's Disease Genomic Consortium (IPDGC), totalling 39 087 individuals (16 642 c2023-01-01T00:00:00Z2023 Jan2026-05-15T03:20:26.989Z2025-02-19T02:23:29.029ZS-EPMC100607203634747110.1093/brain/awac301