{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(12)"],"submitter":["Mehmood H"],"pubmed_abstract":["A novel series of fluorophenyl-based thiazoles was synthesized following the Hanztsch method. All of the compounds were initially verified with physical parameters (color, melting point, retardation factor (<i>R</i> <sub>f</sub>)), which were further confirmed by several spectroscopic methods, including ultraviolet-visible (UV-visible), Fourier-transform infrared (FTIR), <sup>1</sup>H, <sup>13</sup>C, <sup>19</sup>F NMR, and high-resolution mass spectrometry (HRMS). The binding interactions of all compounds were studied using a molecular docking simulation approach. Furthermore, each compound was evaluated for its alpha(α)-amylase, antiglycation, and antioxidant potentials. The biocompatibility of all compounds was checked with an <i>in vitro</i> hemolytic assay. All synthesized scaffolds "],"journal":["ACS omega"],"pagination":["11433-11446"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10061536"],"repository":["biostudies-literature"],"pubmed_title":["Synthesis of Fluorinated Hydrazinylthiazole Derivatives: A Virtual and Experimental Approach to Diabetes Management."],"pmcid":["PMC10061536"],"pubmed_authors":["Perveen S","Akhtar T","Orfali R","Khalid M","Mehmood H","Haroon M","Woodward S","Asghar MA","Baby R"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis of Fluorinated Hydrazinylthiazole Derivatives: A Virtual and Experimental Approach to Diabetes Management.","description":"A novel series of fluorophenyl-based thiazoles was synthesized following the Hanztsch method. All of the compounds were initially verified with physical parameters (color, melting point, retardation factor (<i>R</i> <sub>f</sub>)), which were further confirmed by several spectroscopic methods, including ultraviolet-visible (UV-visible), Fourier-transform infrared (FTIR), <sup>1</sup>H, <sup>13</sup>C, <sup>19</sup>F NMR, and high-resolution mass spectrometry (HRMS). The binding interactions of all compounds were studied using a molecular docking simulation approach. Furthermore, each compound was evaluated for its alpha(α)-amylase, antiglycation, and antioxidant potentials. The biocompatibility of all compounds was checked with an <i>in vitro</i> hemolytic assay. All synthesized scaffolds ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-04-05T13:22:03.456Z","creation":"2025-04-05T13:22:03.456Z"},"accession":"S-EPMC10061536","cross_references":{"pubmed":["37008089"],"doi":["10.1021/acsomega.3c00265"]}}