biostudies-literatureUnknown8(12)Mehmood HA novel series of fluorophenyl-based thiazoles was synthesized following the Hanztsch method. All of the compounds were initially verified with physical parameters (color, melting point, retardation factor (<i>R</i> _f)), which were further confirmed by several spectroscopic methods, including ultraviolet-visible (UV-visible), Fourier-transform infrared (FTIR), ¹H, ¹³C, ¹⁹F NMR, and high-resolution mass spectrometry (HRMS). The binding interactions of all compounds were studied using a molecular docking simulation approach. Furthermore, each compound was evaluated for its alpha(α)-amylase, antiglycation, and antioxidant potentials. The biocompatibility of all compounds was checked with an <i>in vitro</i> hemolytic assay. All synthesized scaffolds ACS omega11433-11446https://www.ebi.ac.uk/biostudies/studies/S-EPMC10061536biostudies-literatureSynthesis of Fluorinated Hydrazinylthiazole Derivatives: A Virtual and Experimental Approach to Diabetes Management.PMC10061536Perveen SAkhtar TOrfali RKhalid MMehmood HHaroon MWoodward SAsghar MABaby RfalseSynthesis of Fluorinated Hydrazinylthiazole Derivatives: A Virtual and Experimental Approach to Diabetes Management.A novel series of fluorophenyl-based thiazoles was synthesized following the Hanztsch method. All of the compounds were initially verified with physical parameters (color, melting point, retardation factor (<i>R</i> _f)), which were further confirmed by several spectroscopic methods, including ultraviolet-visible (UV-visible), Fourier-transform infrared (FTIR), ¹H, ¹³C, ¹⁹F NMR, and high-resolution mass spectrometry (HRMS). The binding interactions of all compounds were studied using a molecular docking simulation approach. Furthermore, each compound was evaluated for its alpha(α)-amylase, antiglycation, and antioxidant potentials. The biocompatibility of all compounds was checked with an <i>in vitro</i> hemolytic assay. All synthesized scaffolds 2023-01-01T00:00:00Z2023 Mar2025-04-05T13:22:03.456Z2025-04-05T13:22:03.456ZS-EPMC100615363700808910.1021/acsomega.3c00265