biostudies-literatureLi TNatural Science Foundation of Zhejiang Province295https://www.ebi.ac.uk/biostudies/studies/S-EPMC10064697biostudies-literatureUnknown23(1)<h4>Background</h4>The prognostic value of cytokeratin 19 fragment (CYFRA 21 - 1) and Ki67 in advanced non-small cell lung cancer (NSCLC) patients with wild-type epidermal growth factor receptor (EGFR) remains to be explored.<h4>Methods</h4>In this study, 983 primary NSCLC patients from January 2016 to December 2019 were retrospectively reviewed. Finally, 117 advanced NSCLC patients with wild-type EGFR and 37 patients with EGFR mutation were included and prognostic value of CYFRA 21 - 1 and Ki67 were also identified.<h4>Results</h4>The patients age, smoking history and the Eastern Corporative Oncology Group (ECOG) performance scores were significantly different between CYFRA21-1 positive and negative groups (p < 0.05), while no significant differences were found in Ki67 high and low groupsBMC cancerPrognostic value of CYFRA 21 - 1 and Ki67 in advanced NSCLC patients with wild-type EGFR.PMC10064697LY18H200006Zheng XQWang XMLi TLuo ZYan GLFang YYXie QSun YHe JBfalsePrognostic value of CYFRA 21 - 1 and Ki67 in advanced NSCLC patients with wild-type EGFR.<h4>Background</h4>The prognostic value of cytokeratin 19 fragment (CYFRA 21 - 1) and Ki67 in advanced non-small cell lung cancer (NSCLC) patients with wild-type epidermal growth factor receptor (EGFR) remains to be explored.<h4>Methods</h4>In this study, 983 primary NSCLC patients from January 2016 to December 2019 were retrospectively reviewed. Finally, 117 advanced NSCLC patients with wild-type EGFR and 37 patients with EGFR mutation were included and prognostic value of CYFRA 21 - 1 and Ki67 were also identified.<h4>Results</h4>The patients age, smoking history and the Eastern Corporative Oncology Group (ECOG) performance scores were significantly different between CYFRA21-1 positive and negative groups (p < 0.05), while no significant differences were found in Ki67 high and low groups2023-01-01T00:00:00Z2023 Mar2025-05-29T19:45:53.434Z2025-04-04T21:10:09.508ZS-EPMC100646973700400410.1186/s12885-023-10767-9