{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Choi MY"],"funding":["Novo Nordisk Foundation","Ministry for Health and Welfare, Republic of Korea","National Institute for Health Research Manchester Biomedical Research Centre","Arthritis Society","NCATS NIH HHS","NCRR NIH HHS","Korea Healthcare","Canadian Institutes of Health Research","Canada Research Chairs","CIHR","Department of Education, Universities and Research of the Basque Government","LUPUS UK","Lupus Foundation of America","London Hospitals Biomedical Research Centre","National Institute for Health Research (NIHR)","NIAMS NIH HHS","Wellcome Trust","Gigtforeningen","Sandwell and West Birmingham Hospitals NHS Trust","Singer Family Fund for Lupus Research"],"pagination":["1143-1150"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10066935"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["81(8)"],"pubmed_abstract":["<h4>Objectives</h4>A perception derived from cross-sectional studies of small systemic lupus erythematosus (SLE) cohorts is that there is a marked discrepancy between antinuclear antibody (ANA) assays, which impacts on clinicians' approach to diagnosis and follow-up. We compared three ANA assays in a longitudinal analysis of a large international incident SLE cohort retested regularly and followed for 5 years.<h4>Methods</h4>Demographic, clinical and serological data was from 805 SLE patients at enrolment, year 3 and 5. Two HEp-2 indirect immunofluorescence assays (IFA1, IFA2), an ANA ELISA, and SLE-related autoantibodies were performed in one laboratory. Frequencies of positivity, titres or absorbance units (AU), and IFA patterns were compared using McNemar, Wilcoxon and kappa statistics,"],"journal":["Annals of the rheumatic diseases"],"pubmed_title":["Longitudinal analysis of ANA in the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort."],"pmcid":["PMC10066935"],"funding_grant_id":["UL1 TR000150","A120404","Manchester Clinical Research Facility","AR069572","NF-SI-0512-10105","A1028","R01 AR046588","P60AR064464","RR00046","AR043727","R01 AR069572","Clinical Research Facility in Birmingham","UL1 RR025741","Systemic Autoimmune Rheumatic Diseases at Universi","A05990","MOP-88526","R01 AR043727","K24-AR-02318","Research Chair in Rheumatic Diseases at the Univer","NF-SI-0617-10075","1U54TR001353","P60 AR064464","UL-1RR-025741","K24 AR002138","K24 AR002213","K24 AR066109","P60 AR048098","AR046588","Gary S Gilkeson Career Development Award","Distinguished Senior Investigator of The Arthritis"],"pubmed_authors":["Lim S","Wallace DJ","Kalunian K","Petri M","Choi MY","Dooley MA","Buyon JP","Clarke AE","Sanchez-Guerrero J","Manzi S","Jonsen A","Fortin PR","Fritzler MJ","Peschken C","Alarcon GS","Rahman A","Bernatsky S","Bruce IN","Costenbader KH","Ginzler EM","Ramsey-Goldman R","St-Pierre Y","Romero-Diaz J","Gladman DD","Merrill JT","Hanly J","Bae SC","Ruiz-Irastorza G","Askanase A","Aranow C","Urowitz M","Gordon C","Inanc M","Mackay M","van Vollenhoven RF","Isenberg D","Kamen DL","Jacobsen S"],"additional_accession":[]},"is_claimable":false,"name":"Longitudinal analysis of ANA in the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort.","description":"<h4>Objectives</h4>A perception derived from cross-sectional studies of small systemic lupus erythematosus (SLE) cohorts is that there is a marked discrepancy between antinuclear antibody (ANA) assays, which impacts on clinicians' approach to diagnosis and follow-up. We compared three ANA assays in a longitudinal analysis of a large international incident SLE cohort retested regularly and followed for 5 years.<h4>Methods</h4>Demographic, clinical and serological data was from 805 SLE patients at enrolment, year 3 and 5. Two HEp-2 indirect immunofluorescence assays (IFA1, IFA2), an ANA ELISA, and SLE-related autoantibodies were performed in one laboratory. Frequencies of positivity, titres or absorbance units (AU), and IFA patterns were compared using McNemar, Wilcoxon and kappa statistics,","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-04T21:09:58.076Z","creation":"2025-04-04T21:09:58.076Z"},"accession":"S-EPMC10066935","cross_references":{"pubmed":["35338033"],"doi":["10.1136/annrheumdis-2022-222168"]}}