biostudies-literatureMarcin TSwiss National Science Foundatione072649https://www.ebi.ac.uk/biostudies/studies/S-EPMC10069571biostudies-literatureUnknown13(3)<h4>Introduction</h4>Computerised diagnostic decision support systems (CDDS) suggesting differential diagnoses to physicians aim to improve clinical reasoning and diagnostic quality. However, controlled clinical trials investigating their effectiveness and safety are absent and the consequences of its use in clinical practice are unknown. We aim to investigate the effect of CDDS use in the emergency department (ED) on diagnostic quality, workflow, resource consumption and patient outcomes.<h4>Methods and analysis</h4>This is a multicentre, outcome assessor and patient-blinded, cluster-randomised, multiperiod crossover superiority trial. A validated differential diagnosis generator will be implemented in four EDs and randomly allocated to a sequence of six alternating intervention and contrBMJ openEffects of a computerised diagnostic decision support tool on diagnostic quality in emergency departments: study protocol of the DDx-BRO multicentre cluster randomised cross-over trial.PMC10069571187284Muller MExadaktylos AKGriesshammer ISauter TCNendaz MBosbach SSingh HLindner GSchauber SKSchwappach DZwaan LKrummrey GHautz SCMarcin THautz WELambrigger CfalseEffects of a computerised diagnostic decision support tool on diagnostic quality in emergency departments: study protocol of the DDx-BRO multicentre cluster randomised cross-over trial.<h4>Introduction</h4>Computerised diagnostic decision support systems (CDDS) suggesting differential diagnoses to physicians aim to improve clinical reasoning and diagnostic quality. However, controlled clinical trials investigating their effectiveness and safety are absent and the consequences of its use in clinical practice are unknown. We aim to investigate the effect of CDDS use in the emergency department (ED) on diagnostic quality, workflow, resource consumption and patient outcomes.<h4>Methods and analysis</h4>This is a multicentre, outcome assessor and patient-blinded, cluster-randomised, multiperiod crossover superiority trial. A validated differential diagnosis generator will be implemented in four EDs and randomly allocated to a sequence of six alternating intervention and contr2023-01-01T00:00:00Z2023 Mar2026-05-28T08:28:50.935Z2025-04-04T10:42:12.638ZS-EPMC100695713699048210.1136/bmjopen-2023-072649