biostudies-literatureLai YShandong Provincial Key Research and Development ProgramShandong Province Agricultural Major Applied Technology Innovation Project59https://www.ebi.ac.uk/biostudies/studies/S-EPMC10071666biostudies-literatureUnknown16(1)<h4>Background</h4>Keratin, the main component of chicken feather, is the third most abundant material after cellulose and chitin. Keratin can be converted into high-value compounds and is considered a potential high-quality protein supplement; However, its recalcitrance makes its breakdown a challenge, and the mechanisms of action of keratinolytic proteases-mediated keratinous substrates degradation are not yet fully elucidated. Bacillus sp. CN2, having many protease-coding genes, is a dominant species in keratin-rich materials environments. To explore the degradation patterns of feather keratin, in this study, we investigated the characteristics of feather degradation by strain CN2 based on the functional-degradomics technology.<h4>Results</h4>Bacillus sp. CN2 showed strong feather keratBiotechnology for biofuels and bioproductsInsights into the keratin efficient degradation mechanism mediated by Bacillus sp. CN2 based on integrating functional degradomics.PMC10071666SD2019ZZ0182021CXGC010803Li WLai YZheng XWu XWang LfalseInsights into the keratin efficient degradation mechanism mediated by Bacillus sp. CN2 based on integrating functional degradomics.<h4>Background</h4>Keratin, the main component of chicken feather, is the third most abundant material after cellulose and chitin. Keratin can be converted into high-value compounds and is considered a potential high-quality protein supplement; However, its recalcitrance makes its breakdown a challenge, and the mechanisms of action of keratinolytic proteases-mediated keratinous substrates degradation are not yet fully elucidated. Bacillus sp. CN2, having many protease-coding genes, is a dominant species in keratin-rich materials environments. To explore the degradation patterns of feather keratin, in this study, we investigated the characteristics of feather degradation by strain CN2 based on the functional-degradomics technology.<h4>Results</h4>Bacillus sp. CN2 showed strong feather kerat2023-01-01T00:00:00Z2023 Apr2025-04-22T13:07:28.572Z2024-11-12T16:41:57.362ZS-EPMC100716663701645310.1186/s13068-023-02308-0