{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(1)"],"submitter":["Mayoh C"],"funding":["Steven Walter children&apos;s cancer foundation","Tour de cure","Luminesce Alliance","Australian Lions Children&apos;s Cancer Research Foundation","Cure Brain Cancer Foundation","Kids Cancer Alliance","Kids&apos; Cancer Project","Cancer Institute NSW","National Health and Medical Research Council"],"pubmed_abstract":["<h4>Background</h4>Molecular profiling of the tumour immune microenvironment (TIME) has enabled the rational choice of immunotherapies in some adult cancers. In contrast, the TIME of paediatric cancers is relatively unexplored. We speculated that a more refined appreciation of the TIME in childhood cancers, rather than a reliance on commonly used biomarkers such as tumour mutation burden (TMB), neoantigen load and PD-L1 expression, is an essential prerequisite for improved immunotherapies in childhood solid cancers.<h4>Methods</h4>We combined immunohistochemistry (IHC) with RNA sequencing and whole-genome sequencing across a diverse spectrum of high-risk paediatric cancers to develop an alternative, expression-based signature associated with CD8<sup>+</sup> T-cell infiltration of the TIME."],"journal":["Genome medicine"],"pagination":["20"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10071693"],"repository":["biostudies-literature"],"pubmed_title":["A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer."],"pmcid":["PMC10071693"],"pubmed_authors":["Rao P","Nicholls W","Zhukova N","Qin V","Bowen-James R","Gifford AJ","Ziegler DS","Miller KE","Saletta F","Senapati A","Tapp H","Ekert PG","Haber M","Terry R","Wong M","Meyran D","Gottardo NG","Moore AS","Khaw SL","Wood PJ","Shai-Hee T","Hansford JR","Mayoh C","Dholaria H","Catchpoole D","Cottrell CE","Tyrrell V","Omer N","Neeson PJ","Trapani JA","Cowley MJ","Alvaro F","Govender D","Yuksel A","Mateos MK","Vittorio O","Lau LMS","Pozza LD","Mardis ER","Mould EVA","Marshall GM","Diamond Y","McCowage G","Khuong-Quang DA"],"additional_accession":[]},"is_claimable":false,"name":"A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer.","description":"<h4>Background</h4>Molecular profiling of the tumour immune microenvironment (TIME) has enabled the rational choice of immunotherapies in some adult cancers. In contrast, the TIME of paediatric cancers is relatively unexplored. We speculated that a more refined appreciation of the TIME in childhood cancers, rather than a reliance on commonly used biomarkers such as tumour mutation burden (TMB), neoantigen load and PD-L1 expression, is an essential prerequisite for improved immunotherapies in childhood solid cancers.<h4>Methods</h4>We combined immunohistochemistry (IHC) with RNA sequencing and whole-genome sequencing across a diverse spectrum of high-risk paediatric cancers to develop an alternative, expression-based signature associated with CD8<sup>+</sup> T-cell infiltration of the TIME.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2026-05-28T22:42:33.483Z","creation":"2024-11-12T15:30:37.911Z"},"accession":"S-EPMC10071693","cross_references":{"pubmed":["37013636"],"doi":["10.1186/s13073-023-01170-x"]}}