biostudies-literatureUnknown18(1)Ismail JNCancer Research SocietyAmerican University of BeirutTen-Eleven Translocation (TET) proteins have recently come to light as important epigenetic regulators conserved in multicellular organisms. TET knockdown studies in rodents have highlighted the critical role of these proteins for proper brain development and function. Mutations in mammalian mTET proteins and mTET2 specifically are frequent and deregulated in leukaemia and glioma respectively. Accordingly, we examined the role of mTET2 in tumorigenesis in larval haemocytes and adult heads in <i>Drosophila melanogaster</i>. Our findings showed that expression of mutant and wild type mTET2 resulted in general phenotypic defects in adult flies and accumulation of abdominal melanotic masses. Notably, flies with mTET2-R43G mutation at the N-terminus of mTET2 exhibited locomotor and circadian beEpigenetics2192375https://www.ebi.ac.uk/biostudies/studies/S-EPMC10072067biostudies-literaturePhenotypic and transcriptomic impact of expressing mammalian TET2 in the <i>Drosophila melanogaster</i> model.PMC10072067Ismail JNJabado NMantash SShirinian MHallal MKhoueiry PfalsePhenotypic and transcriptomic impact of expressing mammalian TET2 in the <i>Drosophila melanogaster</i> model.Ten-Eleven Translocation (TET) proteins have recently come to light as important epigenetic regulators conserved in multicellular organisms. TET knockdown studies in rodents have highlighted the critical role of these proteins for proper brain development and function. Mutations in mammalian mTET proteins and mTET2 specifically are frequent and deregulated in leukaemia and glioma respectively. Accordingly, we examined the role of mTET2 in tumorigenesis in larval haemocytes and adult heads in <i>Drosophila melanogaster</i>. Our findings showed that expression of mutant and wild type mTET2 resulted in general phenotypic defects in adult flies and accumulation of abdominal melanotic masses. Notably, flies with mTET2-R43G mutation at the N-terminus of mTET2 exhibited locomotor and circadian be2023-01-01T00:00:00Z2023 Dec2026-04-08T13:47:46.626Z2024-11-08T21:07:20.432ZS-EPMC100720673698912110.1080/15592294.2023.2192375