{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Comolli J"],"funding":["U.S. Air Force","Massachusetts Institute of Technology"],"pagination":["14"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10073063"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(2)"],"pubmed_abstract":["The complex, dynamic environment of the human lower gastrointestinal tract is colonized by hundreds of bacterial species that impact health and performance. Ex vivo study of the functional interactions between microbial community members in conditions representative of those in the gut is an ongoing challenge. We have developed an in vitro 40-plex platform that provides an oxygen gradient to support simultaneous maintenance of microaerobic and anaerobic microbes from the gut microbiome that can aid in rapid characterization of microbial interactions and direct comparison of individual microbiome samples. In this report, we demonstrate that the platform more closely maintained the microbial diversity and composition of human donor fecal microbiome samples than strict anaerobic conditions. T"],"journal":["Biomedical microdevices"],"pubmed_title":["An in vitro platform for study of the human gut microbiome under an oxygen gradient."],"pmcid":["PMC10073063"],"funding_grant_id":["FA8702-15-D-0001"],"pubmed_authors":["Comolli J","Thorsen T","Bobrow J","Guido NJ","Walsh DI","Lennartz CL"],"additional_accession":[]},"is_claimable":false,"name":"An in vitro platform for study of the human gut microbiome under an oxygen gradient.","description":"The complex, dynamic environment of the human lower gastrointestinal tract is colonized by hundreds of bacterial species that impact health and performance. Ex vivo study of the functional interactions between microbial community members in conditions representative of those in the gut is an ongoing challenge. We have developed an in vitro 40-plex platform that provides an oxygen gradient to support simultaneous maintenance of microaerobic and anaerobic microbes from the gut microbiome that can aid in rapid characterization of microbial interactions and direct comparison of individual microbiome samples. In this report, we demonstrate that the platform more closely maintained the microbial diversity and composition of human donor fecal microbiome samples than strict anaerobic conditions. T","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-27T01:36:53.563Z","creation":"2024-11-15T02:38:33.674Z"},"accession":"S-EPMC10073063","cross_references":{"pubmed":["37014472"],"doi":["10.1007/s10544-023-00653-3"]}}