{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wrigglesworth J"],"funding":["NIA NIH HHS","National Health and Medical Research Council"],"pagination":["692-699"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10073334"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["98(5)"],"pubmed_abstract":["<h4>Objective</h4>The role of circulating sex hormones on structural brain ageing is yet to be established. This study explored whether concentrations of circulating sex hormones in older women are associated with the baseline and longitudinal changes in structural brain ageing, defined by the brain-predicted age difference (brain-PAD).<h4>Design</h4>Prospective cohort study using data from NEURO and Sex Hormones in Older Women; substudies of the ASPirin in Reducing Events in the Elderly clinical trial.<h4>Patients</h4>Community-dwelling older women (aged 70+ years).<h4>Measurements</h4>Oestrone, testosterone, dehydroepiandrosterone (DHEA), and sex-hormone binding globulin (SHBG) were quantified from plasma samples collected at baseline. T1-weighted magnetic resonance imaging was performed"],"journal":["Clinical endocrinology"],"pubmed_title":["The association between sex hormones and the change in brain-predicted age difference in older women."],"pmcid":["PMC10073334"],"funding_grant_id":["334047","APP1173690","APP1135727","U01 AG029824","U19 AG062682","1086188","APP1106533","1127060"],"pubmed_authors":["Egan G","Storey E","Ward SA","Woods RL","Bell RJ","Murray AM","Wrigglesworth J","McNeil JJ","Ward PGD","Davis SR","Ryan J","Islam RM","Harding IH","Trevaks RE"],"additional_accession":[]},"is_claimable":false,"name":"The association between sex hormones and the change in brain-predicted age difference in older women.","description":"<h4>Objective</h4>The role of circulating sex hormones on structural brain ageing is yet to be established. This study explored whether concentrations of circulating sex hormones in older women are associated with the baseline and longitudinal changes in structural brain ageing, defined by the brain-predicted age difference (brain-PAD).<h4>Design</h4>Prospective cohort study using data from NEURO and Sex Hormones in Older Women; substudies of the ASPirin in Reducing Events in the Elderly clinical trial.<h4>Patients</h4>Community-dwelling older women (aged 70+ years).<h4>Measurements</h4>Oestrone, testosterone, dehydroepiandrosterone (DHEA), and sex-hormone binding globulin (SHBG) were quantified from plasma samples collected at baseline. T1-weighted magnetic resonance imaging was performed","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2026-06-01T23:38:05.219Z","creation":"2026-05-23T03:08:07.609Z"},"accession":"S-EPMC10073334","cross_references":{"pubmed":["36807922"],"doi":["10.1111/cen.14898"]}}