{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Cao MZ"],"pubmed_abstract":["<h4>Goals</h4>To assess the efficacy and safety of Chinese Medicine Prescription \"W-LHIT\" in subjects with simple obesity, and to explore its potential mechanism of action.<h4>Methods</h4>Thirty-seven patients aged 18 to 60 from Wei-En hospital (Weifang City, Shandong, China), participated in a double blinded, placebo-controlled study. Subjects were randomly divided into 2 groups, 18 in treatment and 19 in placebo group. The treatment group took the \"W-LHIT\" capsules for two months, while the control group received placebo capsules. Both groups accepted healthy lifestyle education materials. After a 2-month treatment, the placebo group transferred to open-label treatment after unblinding.<h4>Results</h4>72.22% participants in the treatment group lost more than 5% of their body weight, comp"],"journal":["Frontiers in endocrinology"],"pagination":["1054674"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10073537"],"repository":["biostudies-literature"],"pubmed_title":["Clinical efficacy of weight loss herbal intervention therapy and lifestyle modifications on obesity and its association with distinct gut microbiome: A randomized double-blind phase 2 study."],"pmcid":["PMC10073537"],"pubmed_authors":["Chung D","Wen MC","Cao MZ","Yang N","Li XM","Srivastava K","Shi YM","Miao M","Wei CH","Song Y"],"additional_accession":[]},"is_claimable":false,"name":"Clinical efficacy of weight loss herbal intervention therapy and lifestyle modifications on obesity and its association with distinct gut microbiome: A randomized double-blind phase 2 study.","description":"<h4>Goals</h4>To assess the efficacy and safety of Chinese Medicine Prescription \"W-LHIT\" in subjects with simple obesity, and to explore its potential mechanism of action.<h4>Methods</h4>Thirty-seven patients aged 18 to 60 from Wei-En hospital (Weifang City, Shandong, China), participated in a double blinded, placebo-controlled study. Subjects were randomly divided into 2 groups, 18 in treatment and 19 in placebo group. The treatment group took the \"W-LHIT\" capsules for two months, while the control group received placebo capsules. Both groups accepted healthy lifestyle education materials. After a 2-month treatment, the placebo group transferred to open-label treatment after unblinding.<h4>Results</h4>72.22% participants in the treatment group lost more than 5% of their body weight, comp","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-04-30T13:02:48.974Z","creation":"2025-02-19T02:26:11.512Z"},"accession":"S-EPMC10073537","cross_references":{"pubmed":["37033234"],"doi":["10.3389/fendo.2023.1054674"]}}