biostudies-literatureUnknown14Cao MZ<h4>Goals</h4>To assess the efficacy and safety of Chinese Medicine Prescription "W-LHIT" in subjects with simple obesity, and to explore its potential mechanism of action.<h4>Methods</h4>Thirty-seven patients aged 18 to 60 from Wei-En hospital (Weifang City, Shandong, China), participated in a double blinded, placebo-controlled study. Subjects were randomly divided into 2 groups, 18 in treatment and 19 in placebo group. The treatment group took the "W-LHIT" capsules for two months, while the control group received placebo capsules. Both groups accepted healthy lifestyle education materials. After a 2-month treatment, the placebo group transferred to open-label treatment after unblinding.<h4>Results</h4>72.22% participants in the treatment group lost more than 5% of their body weight, compFrontiers in endocrinology1054674https://www.ebi.ac.uk/biostudies/studies/S-EPMC10073537biostudies-literatureClinical efficacy of weight loss herbal intervention therapy and lifestyle modifications on obesity and its association with distinct gut microbiome: A randomized double-blind phase 2 study.PMC10073537Chung DWen MCCao MZYang NLi XMSrivastava KShi YMMiao MWei CHSong YfalseClinical efficacy of weight loss herbal intervention therapy and lifestyle modifications on obesity and its association with distinct gut microbiome: A randomized double-blind phase 2 study.<h4>Goals</h4>To assess the efficacy and safety of Chinese Medicine Prescription "W-LHIT" in subjects with simple obesity, and to explore its potential mechanism of action.<h4>Methods</h4>Thirty-seven patients aged 18 to 60 from Wei-En hospital (Weifang City, Shandong, China), participated in a double blinded, placebo-controlled study. Subjects were randomly divided into 2 groups, 18 in treatment and 19 in placebo group. The treatment group took the "W-LHIT" capsules for two months, while the control group received placebo capsules. Both groups accepted healthy lifestyle education materials. After a 2-month treatment, the placebo group transferred to open-label treatment after unblinding.<h4>Results</h4>72.22% participants in the treatment group lost more than 5% of their body weight, comp2023-01-01T00:00:00Z20232026-04-30T13:02:48.974Z2025-02-19T02:26:11.512ZS-EPMC100735373703323410.3389/fendo.2023.1054674