{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Chang R"],"pubmed_abstract":["<h4>Introduction</h4>Dysregulated macrophage polarization (excessive M1-like or limited M2-like macrophages) in the early decidua contributes to allogeneic fetal rejection and thus early spontaneous abortion. However, the modulators of M1/M2 balance at the early maternal-fetal interface remain mostly unknown.<h4>Methods</h4>First-trimester decidual tissues were collected from normal pregnant women undergoing elective pregnancy terminations and patients with spontaneous abortion. We measured the expression of placental growth factor (PlGF) and Fms-like-tyrosine-kinase receptor 1 (FLT-1), and characterized the profiles of macrophages in decidua. Notably, we investigated the effect of recombinant human PlGF (rhPlGF) on decidual macrophages (dMφs) from normal pregnancy and revealed the underly"],"journal":["Frontiers in immunology"],"pagination":["1061949"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10074254"],"repository":["biostudies-literature"],"pubmed_title":["PlGF/FLT-1 deficiency leads to reduced STAT3-C/EBPβ signaling and aberrant polarization in decidual macrophages during early spontaneous abortion."],"pmcid":["PMC10074254"],"pubmed_authors":["Liu H","Liu X","He F","Jiang L","Chang R","Jiang H","Hu L","Dai J","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"PlGF/FLT-1 deficiency leads to reduced STAT3-C/EBPβ signaling and aberrant polarization in decidual macrophages during early spontaneous abortion.","description":"<h4>Introduction</h4>Dysregulated macrophage polarization (excessive M1-like or limited M2-like macrophages) in the early decidua contributes to allogeneic fetal rejection and thus early spontaneous abortion. However, the modulators of M1/M2 balance at the early maternal-fetal interface remain mostly unknown.<h4>Methods</h4>First-trimester decidual tissues were collected from normal pregnant women undergoing elective pregnancy terminations and patients with spontaneous abortion. We measured the expression of placental growth factor (PlGF) and Fms-like-tyrosine-kinase receptor 1 (FLT-1), and characterized the profiles of macrophages in decidua. Notably, we investigated the effect of recombinant human PlGF (rhPlGF) on decidual macrophages (dMφs) from normal pregnancy and revealed the underly","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-03-31T11:23:15.902Z","creation":"2025-02-19T01:33:08.253Z"},"accession":"S-EPMC10074254","cross_references":{"pubmed":["37033974"],"doi":["10.3389/fimmu.2023.1061949"]}}