biostudies-literatureUnknown14(14)Yang YWe disclosed herein a straightforward strategy for the synthesis of unprecedented <i>N</i>-((trifluoromethyl)thio), <i>N</i>-(trifluoromethyl) amines using a combination of isothiocyanates with a fluoride source and an electrophilic trifluoromethylthiolation reagent. More interestingly, the scalability of the methodology has been demonstrated and the stability of the new motif has been studied.Chemical science3893-3898https://www.ebi.ac.uk/biostudies/studies/S-EPMC10074438biostudies-literatureNovel N(SCF₃)(CF₃)-amines: synthesis, scalability and stability.PMC10074438Yang YSaffon-Merceron NVantourout JCTlili AfalseNovel N(SCF₃)(CF₃)-amines: synthesis, scalability and stability.We disclosed herein a straightforward strategy for the synthesis of unprecedented <i>N</i>-((trifluoromethyl)thio), <i>N</i>-(trifluoromethyl) amines using a combination of isothiocyanates with a fluoride source and an electrophilic trifluoromethylthiolation reagent. More interestingly, the scalability of the methodology has been demonstrated and the stability of the new motif has been studied.2023-01-01T00:00:00Z2023 Apr2025-04-05T12:18:30.685Z2025-04-05T12:18:30.685ZS-EPMC100744383703570910.1039/d2sc06542h