{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ames JL"],"funding":["NICHD NIH HHS","NIEHS NIH HHS","NIH HHS","NIGMS NIH HHS"],"pagination":["450-459"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10074577"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["34(3)"],"pubmed_abstract":["<h4>Background</h4>Epidemiologic evidence linking prenatal exposure to per- and polyfluoroalkyl substances (PFAS) with altered neurodevelopment is inconclusive, and few large studies have focused on autism-related outcomes. We investigated whether blood concentrations of PFAS in pregnancy are associated with child autism-related outcomes.<h4>Methods</h4>We included 10 cohorts from the National Institutes of Health (NIH)-funded Environmental influences on Child Health Outcomes (ECHO) program (n = 1,429). We measured 14 PFAS analytes in maternal blood collected during pregnancy; eight analytes met detection criteria for analysis. We assessed quantitative autism-related traits in children via parent report on the Social Responsiveness Scale (SRS). In multivariable linear models, we examined relationships of each PFAS (natural log-transformed) with SRS scores. We further modeled PFAS as a complex mixture using Bayesian methods and examined modification of these relationships by child sex.<h4>Results</h4>Most PFAS in maternal blood were not associated with child SRS T-scores. Perfluorononanoic acid (PFNA) showed the strongest and most consistent association: each 1-unit increase in ln-transformed PFNA was associated with greater autism-related traits (adjusted β [95% confidence interval (CI)] = 1.5 [-0.1, 3.0]). The summed mixture, which included six PFAS detected in >70% of participants, was not associated with SRS T-scores (adjusted β [95% highest posterior density interval] = 0.7 [-1.4, 3.0]). We did not observe consistent evidence of sex differences.<h4>Conclusions</h4>Prenatal blood concentrations of PFNA may be associated with modest increases in child autism-related traits. Future work should continue to examine the relationship between exposures to both legacy and emerging PFAS and additional dimensional, quantitative measures of childhood autism-related outcomes."],"journal":["Epidemiology (Cambridge, Mass.)"],"pubmed_title":["Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Childhood Autism-related Outcomes."],"pmcid":["PMC10074577"],"funding_grant_id":["UG3 OD023318","K99 ES032481","P30 ES030284","R24 ES029490","U24 OD023319","UG3 OD023272","UH3 OD023272","UH3 OD023275","U2C OD023375","UH3 OD023318","U24 OD023382","U2C ES026542","R01 HD083369","UG3 OD023348","P30 ES010126","R01 ES027051","P20 GM104416","UH3 OD023289","UH3 OD023365","UH3 OD023342","UH3 OD023286","UH3 OD023348","UH3 OD023248","P01 ES022841","R00 ES032481","UH3 OD023349"],"pubmed_authors":["Lyall K","Braun JM","Dunlop AL","Zhu Y","Oh J","Lin PD","Woodruff TJ","Croen LA","O'Connor TG","Burjak M","Morello-Frosch R","Ames JL","Liang D","Avalos LA","Karagas MR","Fry RC","Bulka CM","Moore B","Ferrara A","program collaborators for Environmental influences on Child Health Outcomes","Padula AM","Hamra GB","Hedderson MM"],"additional_accession":[]},"is_claimable":false,"name":"Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Childhood Autism-related Outcomes.","description":"<h4>Background</h4>Epidemiologic evidence linking prenatal exposure to per- and polyfluoroalkyl substances (PFAS) with altered neurodevelopment is inconclusive, and few large studies have focused on autism-related outcomes. We investigated whether blood concentrations of PFAS in pregnancy are associated with child autism-related outcomes.<h4>Methods</h4>We included 10 cohorts from the National Institutes of Health (NIH)-funded Environmental influences on Child Health Outcomes (ECHO) program (n = 1,429). We measured 14 PFAS analytes in maternal blood collected during pregnancy; eight analytes met detection criteria for analysis. We assessed quantitative autism-related traits in children via parent report on the Social Responsiveness Scale (SRS). In multivariable linear models, we examined relationships of each PFAS (natural log-transformed) with SRS scores. We further modeled PFAS as a complex mixture using Bayesian methods and examined modification of these relationships by child sex.<h4>Results</h4>Most PFAS in maternal blood were not associated with child SRS T-scores. Perfluorononanoic acid (PFNA) showed the strongest and most consistent association: each 1-unit increase in ln-transformed PFNA was associated with greater autism-related traits (adjusted β [95% confidence interval (CI)] = 1.5 [-0.1, 3.0]). The summed mixture, which included six PFAS detected in >70% of participants, was not associated with SRS T-scores (adjusted β [95% highest posterior density interval] = 0.7 [-1.4, 3.0]). We did not observe consistent evidence of sex differences.<h4>Conclusions</h4>Prenatal blood concentrations of PFNA may be associated with modest increases in child autism-related traits. Future work should continue to examine the relationship between exposures to both legacy and emerging PFAS and additional dimensional, quantitative measures of childhood autism-related outcomes.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2025-04-21T15:12:41.82Z","creation":"2025-02-19T02:04:14.362Z"},"accession":"S-EPMC10074577","cross_references":{"pubmed":["36630444"],"doi":["10.1097/ede.0000000000001587","10.1097/EDE.0000000000001587"]}}