{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tan Y"],"funding":["National Natural Science Foundation of China"],"pagination":["1149810"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10076825"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14"],"pubmed_abstract":["<h4>Background</h4>Patients with diabetes mellitus (DM) have a higher incidence of malignant tumors than people without diabetes, but the underlying molecular mechanisms are still unclear.<h4>Methods</h4>To investigate the link between DM and cancer, we screened publicly available databases for diabetes and cancer-related genes (DCRGs) and constructed a diabetes-based cancer-associated inflammation network (DCIN). We integrated seven DCRGs into the DCIN and analyzed their role in different tumors from various perspectives. We also investigated drug sensitivity and single-cell sequencing data in colon adenocarcinoma as an example. In addition, we performed <i>in vitro</i> experiments to verify the expression of DCRGs and the arachidonic acid metabolic pathway.<h4>Results</h4>Seven identifie"],"journal":["Frontiers in immunology"],"pubmed_title":["Diabetes mellitus induces a novel inflammatory network involving cancer progression: Insights from bioinformatic analysis and <i>in vitro</i> validation."],"pmcid":["PMC10076825"],"funding_grant_id":["81873169"],"pubmed_authors":["Li H","Liu Y","Zhong A","Peng W","Zhang Z","Tan Y","Kang J","Huang R","Cheng X"],"additional_accession":[]},"is_claimable":false,"name":"Diabetes mellitus induces a novel inflammatory network involving cancer progression: Insights from bioinformatic analysis and <i>in vitro</i> validation.","description":"<h4>Background</h4>Patients with diabetes mellitus (DM) have a higher incidence of malignant tumors than people without diabetes, but the underlying molecular mechanisms are still unclear.<h4>Methods</h4>To investigate the link between DM and cancer, we screened publicly available databases for diabetes and cancer-related genes (DCRGs) and constructed a diabetes-based cancer-associated inflammation network (DCIN). We integrated seven DCRGs into the DCIN and analyzed their role in different tumors from various perspectives. We also investigated drug sensitivity and single-cell sequencing data in colon adenocarcinoma as an example. In addition, we performed <i>in vitro</i> experiments to verify the expression of DCRGs and the arachidonic acid metabolic pathway.<h4>Results</h4>Seven identifie","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-06-27T03:24:51.565Z","creation":"2025-02-19T01:32:43.064Z"},"accession":"S-EPMC10076825","cross_references":{"pubmed":["37033970"],"doi":["10.3389/fimmu.2023.1149810"]}}