biostudies-literatureTan YNational Natural Science Foundation of China1149810https://www.ebi.ac.uk/biostudies/studies/S-EPMC10076825biostudies-literatureUnknown14<h4>Background</h4>Patients with diabetes mellitus (DM) have a higher incidence of malignant tumors than people without diabetes, but the underlying molecular mechanisms are still unclear.<h4>Methods</h4>To investigate the link between DM and cancer, we screened publicly available databases for diabetes and cancer-related genes (DCRGs) and constructed a diabetes-based cancer-associated inflammation network (DCIN). We integrated seven DCRGs into the DCIN and analyzed their role in different tumors from various perspectives. We also investigated drug sensitivity and single-cell sequencing data in colon adenocarcinoma as an example. In addition, we performed <i>in vitro</i> experiments to verify the expression of DCRGs and the arachidonic acid metabolic pathway.<h4>Results</h4>Seven identifieFrontiers in immunologyDiabetes mellitus induces a novel inflammatory network involving cancer progression: Insights from bioinformatic analysis and <i>in vitro</i> validation.PMC1007682581873169Li HLiu YZhong APeng WZhang ZTan YKang JHuang RCheng XfalseDiabetes mellitus induces a novel inflammatory network involving cancer progression: Insights from bioinformatic analysis and <i>in vitro</i> validation.<h4>Background</h4>Patients with diabetes mellitus (DM) have a higher incidence of malignant tumors than people without diabetes, but the underlying molecular mechanisms are still unclear.<h4>Methods</h4>To investigate the link between DM and cancer, we screened publicly available databases for diabetes and cancer-related genes (DCRGs) and constructed a diabetes-based cancer-associated inflammation network (DCIN). We integrated seven DCRGs into the DCIN and analyzed their role in different tumors from various perspectives. We also investigated drug sensitivity and single-cell sequencing data in colon adenocarcinoma as an example. In addition, we performed <i>in vitro</i> experiments to verify the expression of DCRGs and the arachidonic acid metabolic pathway.<h4>Results</h4>Seven identifie2023-01-01T00:00:00Z20232026-06-27T03:24:51.565Z2025-02-19T01:32:43.064ZS-EPMC100768253703397010.3389/fimmu.2023.1149810