biostudies-literatureUnknown11Lenoir M<h4>Background</h4>More than half of infants with complex congenital heart disease (CHD) will have a neurodevelopmental disorder of multifactorial causes. The preoperative period represents a time-window during which neonates with complex CHD are in a state of hypoxia and hemodynamic instability, which fosters the emergence of brain injuries and, thus, affects early brain networks and neurodevelopmental outcomes. Currently, there is no consensus regarding the optimal age for cardiac surgery in terms of neurodevelopmental outcomes, and its definition is a real challenge. Our aim is to determine the relationship between cardiac surgical timing and long-term neurodevelopmental outcomes for various types of complex CHD.<h4>Methods</h4>We hypothesize that earlier surgical timing could representFrontiers in pediatrics1003585https://www.ebi.ac.uk/biostudies/studies/S-EPMC10077148biostudies-literatureImpact of cardiac surgical timing on the neurodevelopmental outcomes of newborns with Complex congenital heart disease (CHD).PMC10077148Lenoir MAl-Dybiat SLebel SGran CGrandvuillemin IGauthier KDesnous BBoubred FAldebert PPeyre MAllary CCarles GFrancois CEl-Louali FDesroberts CRozalen WPaoli FBlanc JFouilloux VTestud BAlaoui MBMichel FBeretti TArnaud SSantelli DResseguier NOvaert CWanert CMilh MSoulatges CfalseImpact of cardiac surgical timing on the neurodevelopmental outcomes of newborns with Complex congenital heart disease (CHD).<h4>Background</h4>More than half of infants with complex congenital heart disease (CHD) will have a neurodevelopmental disorder of multifactorial causes. The preoperative period represents a time-window during which neonates with complex CHD are in a state of hypoxia and hemodynamic instability, which fosters the emergence of brain injuries and, thus, affects early brain networks and neurodevelopmental outcomes. Currently, there is no consensus regarding the optimal age for cardiac surgery in terms of neurodevelopmental outcomes, and its definition is a real challenge. Our aim is to determine the relationship between cardiac surgical timing and long-term neurodevelopmental outcomes for various types of complex CHD.<h4>Methods</h4>We hypothesize that earlier surgical timing could represent2023-01-01T00:00:00Z20232025-04-04T14:29:42.411Z2025-04-04T14:29:42.411ZS-EPMC100771483703318010.3389/fped.2023.1003585