biostudies-literatureUnknown14Hamouzova KThe continuous use of herbicides for controlling weeds has led to the evolution of resistance to all major herbicidal modes of action globally. Every year, new cases of herbicide resistance are reported. Resistance is still in progress in many species, which must be stopped before it becomes a worldwide concern. Several herbicides are known to cause stressful conditions that resemble plant abiotic stresses. Variation in intracellular calcium (Ca²⁺) concentration is a primary event in a wide range of biological processes in plants, including adaptation to various biotic and abiotic stresses. Ca²⁺ acts as a secondary messenger, connecting various environmental stimuli to different biological processes, especially during stress rejoindering in plants. Even though many stFrontiers in plant science1135845https://www.ebi.ac.uk/biostudies/studies/S-EPMC10080077biostudies-literatureCalcium signalling in weeds under herbicide stress: An outlook.PMC10080077Bharati RSoukup JHamouzova KChawdhery MRAKosnarova PSen MKRoy AfalseCalcium signalling in weeds under herbicide stress: An outlook.The continuous use of herbicides for controlling weeds has led to the evolution of resistance to all major herbicidal modes of action globally. Every year, new cases of herbicide resistance are reported. Resistance is still in progress in many species, which must be stopped before it becomes a worldwide concern. Several herbicides are known to cause stressful conditions that resemble plant abiotic stresses. Variation in intracellular calcium (Ca²⁺) concentration is a primary event in a wide range of biological processes in plants, including adaptation to various biotic and abiotic stresses. Ca²⁺ acts as a secondary messenger, connecting various environmental stimuli to different biological processes, especially during stress rejoindering in plants. Even though many st2023-01-01T00:00:00Z20232025-04-19T14:30:06.484Z2025-04-19T14:30:06.484ZS-EPMC100800773703505310.3389/fpls.2023.1135845