biostudies-literatureAdviento BAGlaxoSmithKlineCOPD FoundationNovartis Pharmaceuticals CorporationNational Heart, Lung, and Blood InstituteNHLBI NIH HHS292-302https://www.ebi.ac.uk/biostudies/studies/S-EPMC10083129biostudies-literatureUnknown163(2)<h4>Background</h4>Studies have shown that COPD and smoking are associated with increased suicide risk. To date, there are no prospective studies examining suicide risk among individuals with smoking exposure along a spectrum of pulmonary diseases ranging from normal spirometry to severe COPD.<h4>Research question</h4>Which clinical variables predict death by suicide or overdose of indeterminate intent in a large cohort of individuals with smoking exposure within the Genetic Epidemiology of COPD (COPDGene) study?<h4>Study design and methods</h4>We studied data from 9,930 participants involved in COPDGene, a multisite, prospective cohort study of individuals with smoking exposure. Primary cause of adjudicated deaths was identified by using death certificates, family reports, and medical recChestClinical Markers Associated With Risk of Suicide or Drug Overdose Among Individuals With Smoking Exposure: A Longitudinal Follow-up Study of the COPDGene Cohort.PMC10083129U01 HL089897NCT00608764U01 HL089856Lan CKelsen SDiaz AARuiz MEKinney GLD'Alonzo GMorrow JCharbonnier JPAustin ERosiello RCordova FRoss JCSanchez-Ferrero GVPutcha NPorszasz JVummidi DNardelli PThomashow BShinozaki GBudoff MComellas APMcEvoy CWashko GJacobson FLSoler XNewell JDQiao DWendt CPonce MKunisaki KMBillings JWells JMHorton KBailey WSciurba FDass CKazerooni ERegan EAJudy PFHersh CDransfield MConrad DFischer HHayden LPKluiber AAnzueto AYun JMake BJStringer WCastaldi PJvan Ginneken BWashko GRNath HDesai PSilverman EKBanaei-Kashani FBarr RGMaselli-Caceres DJacobs MNewell JHan MKYohannes AMBeaty THMacIntyre NLynch DASchroeder JShenoy KLowe KECriner GHoffman EANotary AWeissfeld JBon JMake BGhosh AHumphries SCurtis JLLange CCiccolella DFiedorowicz JGCOPDGene InvestigatorsVan Beek EGuntupalli KCenteno JPWestney GLabaki WAustin JStoel BCKim WVeitel LAdams SHersh CPWan ESTashjian JYen AKim VRegan EGalban CJRossiter HVega-Sanchez MEHoth KFHetmanski JYoung KAAllen TThompson BMurray SWise RHansel NNLaird NSieren JHokanson JESteiner RMD'Souza BGalban CGuy EBhatt SPSingh HSharafkhaneh AProkopenko DBowler RPKechris KAdami AForeman MGPace DCasaburi RHanania NAPernicano PGWilson CGSaferali AFlenaugh ELSan Jose Estepar RWashington LMamary AJParulekar ACho MHLutz SMKhatiwada APratte KBowler RStrand MIyer ASakornsakolpat PLambert ADeMeo DLvan Rikxoort EKinney GTerpenning SCoxson HOKazerooni EAHobbs BDBoriek AAdviento BAChandra DMarchetti NIyer ASCrapo JDSatti ABegnaud AMoll MHolm KEAtik MTschirren JJensen RMcAdams HPMcDonald MLBell BCrooks JHanania NGebrekristos HSwift ISwift AEl Boueiz AOh ABrown RfalseClinical Markers Associated With Risk of Suicide or Drug Overdose Among Individuals With Smoking Exposure: A Longitudinal Follow-up Study of the COPDGene Cohort.<h4>Background</h4>Studies have shown that COPD and smoking are associated with increased suicide risk. To date, there are no prospective studies examining suicide risk among individuals with smoking exposure along a spectrum of pulmonary diseases ranging from normal spirometry to severe COPD.<h4>Research question</h4>Which clinical variables predict death by suicide or overdose of indeterminate intent in a large cohort of individuals with smoking exposure within the Genetic Epidemiology of COPD (COPDGene) study?<h4>Study design and methods</h4>We studied data from 9,930 participants involved in COPDGene, a multisite, prospective cohort study of individuals with smoking exposure. Primary cause of adjudicated deaths was identified by using death certificates, family reports, and medical rec2023-01-01T00:00:00Z2023 Feb2025-04-05T10:17:13.676Z2025-04-05T10:17:13.676ZS-EPMC100831293616712010.1016/j.chest.2022.09.022