{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Schijven D"],"funding":["Swiss National Science Foundation","European Research Council","ZonMw"],"pagination":["e2213880120"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10083554"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["120(14)"],"pubmed_abstract":["Left-right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting in equivocal findings. We carried out the largest case-control study of structural brain asymmetries in schizophrenia, with MRI data from 5,080 affected individuals and 6,015 controls across 46 datasets, using a single image analysis protocol. Asymmetry indexes were calculated for global and regional cortical thickness, surface area, and subcortical volume measures. Differences of asymmetry were calculated between affected individuals and controls per dataset, and effect sizes were meta-analyzed across datasets. Small average case-control differences were observed for thickness asymmetr"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium."],"pmcid":["PMC10083554"],"funding_grant_id":["320030","178175","91112002","057216","31000056","91746370","31180002","100002034","100001002","802998","91676084","90802123","91712394","146789","31160003","119382"],"pubmed_authors":["Kahn RS","Hajek T","Mathalon DH","Stephen JM","Luckhoff HK","Murray RM","James A","Surbeck W","Alnæs D","Bruggemann JM","Uhlmann A","Rasser PE","Vazquez-Bourgon J","Lois NG","Kim WS","Crespo-Facorro B","Catts SV","Dazzan P","Chung YC","Grotegerd D","Antonucci LA","Homan P","Homan S","de Zwarte SMC","Brosch K","Kaiser S","Pineda-Zapata JA","Ringwald KG","Georgiadis F","Scheffler F","Westlye LT","Kochunov P","Fazio L","Schijven D","Scott RJ","Kramer B","Pantelis C","Calhoun VD","Guerrero-Pedraza A","Skoch A","Ciullo V","Arango C","Miura K","Gruber O","Knochel C","Piras F","Fuentes-Claramonte P","Henskens FA","Nenadic I","Franke B","Kim M","Pergola G","Spaniel F","Fan F","Turner JA","Sarro S","Diaz-Zuluaga AM","Hashimoto R","Stein F","Preda A","Glahn DC","Michielse S","Michie PT","Gur RC","Janssen J","du Plessis S","Ortiz-Garcia de la Foz V","Francks C","Salvador R","Hulshoff Pol HE","Jansen A","Mayer AR","Luders E","Sellgren CM","Stein DJ","Agartz I","Dannlowski U","Ford JM","Tomyshev AS","van Erp TGM","Fukunaga M","Postema MC","Weickert CS","Schmidt A","Lawrie SM","de Haan L","Diaz-Caneja CM","Ehrlich S","Whalley HC","Emsley R","Loughland CM","Schall U","Temmingh HS","Andreassen OA","Bernardoni F","Carr VJ","Vecchio D","Fisher SE","Medland SE","Weickert TW","Dickie EW","Banaj N","Ayesa-Arriola R","Wang Z","Tordesillas-Gutierrez D","Bustillo J","Chen J","Rootes-Murdy K","van Amelsvoort T","Lencer R","Tan Y","Oertel V","Satterthwaite TD","Thompson PM","Kwak YB","Stablein M","Spalletta G","Voineskos AN","Bertolino A","Oh S","Xiang H","Kwon JS","van Haren NEM","Howells FM","Cervenka S","Pomarol-Clotet E","Dahl A","Kircher TTJ","McIntosh AM","Kirschner M","Sim K","Bakker G","Jahanshad N","Cahn W","Edmond JT","Ji E","Borgwardt S","Quide Y","Garcia-Leon MA","Pfarr JK","Lopez-Jaramillo C","Green MJ","Andreou C","Mowry BJ","Ciufolini S","Potkin SG","Lebedeva I","Jonsson EG","Matsumoto J"],"additional_accession":[]},"is_claimable":false,"name":"Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium.","description":"Left-right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting in equivocal findings. We carried out the largest case-control study of structural brain asymmetries in schizophrenia, with MRI data from 5,080 affected individuals and 6,015 controls across 46 datasets, using a single image analysis protocol. Asymmetry indexes were calculated for global and regional cortical thickness, surface area, and subcortical volume measures. Differences of asymmetry were calculated between affected individuals and controls per dataset, and effect sizes were meta-analyzed across datasets. Small average case-control differences were observed for thickness asymmetr","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-25T18:25:34.835Z","creation":"2025-04-06T07:37:06.698Z"},"accession":"S-EPMC10083554","cross_references":{"pubmed":["36976765"],"doi":["10.1073/pnas.2213880120"]}}