{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["55(1)"],"submitter":["McCoy AM"],"funding":["James R. Harkness Fund","University of Illinois Companion Animal Research Grant Funds"],"pubmed_abstract":["<h4>Background</h4>Plantar osteochondral fragments (POF) are common but their effect on joint health of young Standardbreds in race training is largely unknown.<h4>Objectives</h4>Evaluate the inflammatory effects of POF in metatarsophalangeal joints of young Standardbreds as a step towards developing evidence-based recommendations for surgical removal.<h4>Study design</h4>Cohort study.<h4>Methods</h4>Forty-nine Standardbred horses (age 11-33 months) presented for surgical removal of POF from 56 metatarsophalangeal joints. Synovial tissue collected at arthroscopy was subjected to histopathology. IL-1β, TNF-α, and PGE-2 were measured in synovial fluid using ELISA. Digital arthroscopy images were scored for inflammation. Racing performance data were retrieved from a public database.<h4>Result"],"journal":["Equine veterinary journal"],"pagination":["33-41"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10083909"],"repository":["biostudies-literature"],"pubmed_title":["Plantar osteochondral fragments in young Standardbreds are associated with minimal joint inflammation at the time of surgical removal."],"pmcid":["PMC10083909"],"pubmed_authors":["Roady PJ","Secor EJ","Gray SM","Gutierrez-Nibeyro SD","Klein J","McCoy AM"],"additional_accession":[]},"is_claimable":false,"name":"Plantar osteochondral fragments in young Standardbreds are associated with minimal joint inflammation at the time of surgical removal.","description":"<h4>Background</h4>Plantar osteochondral fragments (POF) are common but their effect on joint health of young Standardbreds in race training is largely unknown.<h4>Objectives</h4>Evaluate the inflammatory effects of POF in metatarsophalangeal joints of young Standardbreds as a step towards developing evidence-based recommendations for surgical removal.<h4>Study design</h4>Cohort study.<h4>Methods</h4>Forty-nine Standardbred horses (age 11-33 months) presented for surgical removal of POF from 56 metatarsophalangeal joints. Synovial tissue collected at arthroscopy was subjected to histopathology. IL-1β, TNF-α, and PGE-2 were measured in synovial fluid using ELISA. Digital arthroscopy images were scored for inflammation. Racing performance data were retrieved from a public database.<h4>Result","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-25T18:30:54.503Z","creation":"2025-04-06T07:36:47.614Z"},"accession":"S-EPMC10083909","cross_references":{"pubmed":["35298851"],"doi":["10.1111/evj.13575"]}}