{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(6)"],"submitter":["Fueyo-Marcos E"],"pubmed_abstract":["Antibodies targeting the PD-1 receptor and its ligand PD-L1 have shown impressive responses in some tumors of bad prognosis. We hypothesized that, since immunosuppressive cells might present several immune checkpoints on their surface, the selective elimination of PD-L1 expressing cells could be efficacious in enabling the activation of antitumoral immune responses. To address this question, we developed an inducible suicidal knock-in mouse allele of <i>Pd-l1</i> (PD-L1<sup>ATTAC</sup>) which allows for the tracking and specific elimination of PD-L1-expressing cells in adult tissues. Consistent with our hypothesis, elimination of PD-L1 expressing cells from the mouse peritoneum increased the septic response to lipopolysaccharide (LPS), due to an exacerbated inflammatory response to the endotoxin. In addition, mice depleted of PD-L1<sup>+</sup> cells were resistant to colon cancer peritoneal allografts, which was associated with a loss of immunosuppressive B cells and macrophages, concomitant with an increase in activated cytotoxic CD8 T cells. Collectively, these results illustrate the usefulness of PD-L1<sup>ATTAC</sup> mice for research in immunotherapy and provide genetic support to the concept of targeting PD-L1 expressing cells in cancer."],"journal":["Aging"],"pagination":["1791-1807"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10085585"],"repository":["biostudies-literature"],"pubmed_title":["PD-L1<sup>ATTAC</sup> mice reveal the potential of depleting PD-L1 expressing cells in cancer therapy."],"pmcid":["PMC10085585"],"pubmed_authors":["Al-Shahrour F","Fueyo-Marcos E","Anton ME","Fustero-Torre C","Fernandez-Capetillo O","Lopez-Pernas G","Murga M"],"additional_accession":[]},"is_claimable":false,"name":"PD-L1<sup>ATTAC</sup> mice reveal the potential of depleting PD-L1 expressing cells in cancer therapy.","description":"Antibodies targeting the PD-1 receptor and its ligand PD-L1 have shown impressive responses in some tumors of bad prognosis. We hypothesized that, since immunosuppressive cells might present several immune checkpoints on their surface, the selective elimination of PD-L1 expressing cells could be efficacious in enabling the activation of antitumoral immune responses. To address this question, we developed an inducible suicidal knock-in mouse allele of <i>Pd-l1</i> (PD-L1<sup>ATTAC</sup>) which allows for the tracking and specific elimination of PD-L1-expressing cells in adult tissues. Consistent with our hypothesis, elimination of PD-L1 expressing cells from the mouse peritoneum increased the septic response to lipopolysaccharide (LPS), due to an exacerbated inflammatory response to the endotoxin. In addition, mice depleted of PD-L1<sup>+</sup> cells were resistant to colon cancer peritoneal allografts, which was associated with a loss of immunosuppressive B cells and macrophages, concomitant with an increase in activated cytotoxic CD8 T cells. Collectively, these results illustrate the usefulness of PD-L1<sup>ATTAC</sup> mice for research in immunotherapy and provide genetic support to the concept of targeting PD-L1 expressing cells in cancer.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-04-04T20:38:24.342Z","creation":"2025-04-04T20:38:24.342Z"},"accession":"S-EPMC10085585","cross_references":{"pubmed":["36947705"],"doi":["10.18632/aging.204598"]}}