biostudies-literatureZhang YNCI NIH HHSe2217734120https://www.ebi.ac.uk/biostudies/studies/S-EPMC10089205biostudies-literatureUnknown120(11)Degradable polymer matrices and porous scaffolds provide powerful mechanisms for passive, sustained release of drugs relevant to the treatment of a broad range of diseases and conditions. Growing interest is in active control of pharmacokinetics tailored to the needs of the patient via programmable engineering platforms that include power sources, delivery mechanisms, communication hardware, and associated electronics, most typically in forms that require surgical extraction after a period of use. Here we report a light-controlled, self-powered technology that bypasses key disadvantages of these systems, in an overall design that is bioresorbable. Programmability relies on the use of an external light source to illuminate an implanted, wavelength-sensitive phototransistor to trigger a shorProceedings of the National Academy of Sciences of the United States of AmericaSelf-powered, light-controlled, bioresorbable platforms for programmed drug delivery.PMC10089205P30 CA060553Wu MFranz CKHuang IHu ZJiang FChoi JWang JBouricha YLee GGuo HWang TZhao KD'Andrea DWu YRogers JALantsova ADempsey EWalters JBYoon HJLi SHuang YZhang YNi XBailey KLiu FfalseSelf-powered, light-controlled, bioresorbable platforms for programmed drug delivery.Degradable polymer matrices and porous scaffolds provide powerful mechanisms for passive, sustained release of drugs relevant to the treatment of a broad range of diseases and conditions. Growing interest is in active control of pharmacokinetics tailored to the needs of the patient via programmable engineering platforms that include power sources, delivery mechanisms, communication hardware, and associated electronics, most typically in forms that require surgical extraction after a period of use. Here we report a light-controlled, self-powered technology that bypasses key disadvantages of these systems, in an overall design that is bioresorbable. Programmability relies on the use of an external light source to illuminate an implanted, wavelength-sensitive phototransistor to trigger a shor2023-01-01T00:00:00Z2023 Mar2025-04-21T15:38:59.843Z2025-04-21T15:38:59.843ZS-EPMC100892053688866110.1073/pnas.2217734120