{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(4)"],"submitter":["Witt A"],"pubmed_abstract":["XIAP is a caspase-inhibitory protein that blocks several cell death pathways, and mediates proper activation of inflammatory NOD2-RIP2 signaling. XIAP deficiency in patients with inflammatory diseases such as Crohn's disease, or those needing allogeneic hematopoietic cell transplantation, is associated with a worse prognosis. In this study, we show that XIAP absence sensitizes cells and mice to LPS- and TNF-mediated cell death without affecting LPS- or TNF-induced NF-κB and MAPK signaling. In XIAP deficient mice, RIP1 inhibition effectively blocks TNF-stimulated cell death, hypothermia, lethality, cytokine/chemokine release, intestinal tissue damage and granulocyte migration. By contrast, inhibition of the related kinase RIP2 does not affect TNF-stimulated events, suggesting a lack of invo"],"journal":["Cell death & disease"],"pagination":["262"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10090100"],"repository":["biostudies-literature"],"pubmed_title":["XIAP deletion sensitizes mice to TNF-induced and RIP1-mediated death."],"pmcid":["PMC10090100"],"pubmed_authors":["Witt A","Vucic D","Webster JD","Kist M","Dugger D","Lee YM","Newton K","Eastham J","Dohse M","Goncharov T"],"additional_accession":[]},"is_claimable":false,"name":"XIAP deletion sensitizes mice to TNF-induced and RIP1-mediated death.","description":"XIAP is a caspase-inhibitory protein that blocks several cell death pathways, and mediates proper activation of inflammatory NOD2-RIP2 signaling. XIAP deficiency in patients with inflammatory diseases such as Crohn's disease, or those needing allogeneic hematopoietic cell transplantation, is associated with a worse prognosis. In this study, we show that XIAP absence sensitizes cells and mice to LPS- and TNF-mediated cell death without affecting LPS- or TNF-induced NF-κB and MAPK signaling. In XIAP deficient mice, RIP1 inhibition effectively blocks TNF-stimulated cell death, hypothermia, lethality, cytokine/chemokine release, intestinal tissue damage and granulocyte migration. By contrast, inhibition of the related kinase RIP2 does not affect TNF-stimulated events, suggesting a lack of invo","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-04T12:01:38.267Z","creation":"2025-04-04T12:01:38.267Z"},"accession":"S-EPMC10090100","cross_references":{"pubmed":["37041175"],"doi":["10.1038/s41419-023-05793-1"]}}