{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(1)"],"submitter":["Cheng PN"],"pubmed_abstract":["<h4>Introduction</h4>Hepatitis C (HCV) is associated with extra-hepatic involvment, morbidity as well as metabolic changes. Whether these might be reversible if sustained virologic response (SVR) is achieved by direct-acting antiviral (DAA) therapy remains unknown.<h4>Methods</h4>Chronic hepatitis C (CHC) individuals receiving DAA treatment with SVR were compared to those who underwent spontaneous clearance (SC) of HCV infection at the 2-year follow-up. Plasma oxidative stress markers (oxidized low-density lipoprotein (oxLDL), 8-hydroxy-2'-deoxyguanosine (8-OHdG), malondialdehyde (MDA) and ischemia-modified albumin (IMA)) as well as progression of liver fibrosis were evaluated.<h4>Results</h4>Compared to SC individuals, those in the CHC group exhibited at baseline higher levels of oxLDL, 8"],"journal":["Journal of virus eradication"],"pagination":["100318"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10091014"],"repository":["biostudies-literature"],"pubmed_title":["Reversibility of some oxidative stress markers in chronic hepatitis C patients after receiving direct-acting antiviral agents."],"pmcid":["PMC10091014"],"pubmed_authors":["Sun HY","Young KC","Chien SC","Cheng PN","Feng IC","Chiu HC","Wang ST","Chiu YC"],"additional_accession":[]},"is_claimable":false,"name":"Reversibility of some oxidative stress markers in chronic hepatitis C patients after receiving direct-acting antiviral agents.","description":"<h4>Introduction</h4>Hepatitis C (HCV) is associated with extra-hepatic involvment, morbidity as well as metabolic changes. Whether these might be reversible if sustained virologic response (SVR) is achieved by direct-acting antiviral (DAA) therapy remains unknown.<h4>Methods</h4>Chronic hepatitis C (CHC) individuals receiving DAA treatment with SVR were compared to those who underwent spontaneous clearance (SC) of HCV infection at the 2-year follow-up. Plasma oxidative stress markers (oxidized low-density lipoprotein (oxLDL), 8-hydroxy-2'-deoxyguanosine (8-OHdG), malondialdehyde (MDA) and ischemia-modified albumin (IMA)) as well as progression of liver fibrosis were evaluated.<h4>Results</h4>Compared to SC individuals, those in the CHC group exhibited at baseline higher levels of oxLDL, 8","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-04-04T07:35:02.708Z","creation":"2025-04-04T07:35:02.708Z"},"accession":"S-EPMC10091014","cross_references":{"pubmed":["37065432"],"doi":["10.1016/j.jve.2023.100318"]}}