biostudies-literatureUnknown9(1)Cheng PN<h4>Introduction</h4>Hepatitis C (HCV) is associated with extra-hepatic involvment, morbidity as well as metabolic changes. Whether these might be reversible if sustained virologic response (SVR) is achieved by direct-acting antiviral (DAA) therapy remains unknown.<h4>Methods</h4>Chronic hepatitis C (CHC) individuals receiving DAA treatment with SVR were compared to those who underwent spontaneous clearance (SC) of HCV infection at the 2-year follow-up. Plasma oxidative stress markers (oxidized low-density lipoprotein (oxLDL), 8-hydroxy-2'-deoxyguanosine (8-OHdG), malondialdehyde (MDA) and ischemia-modified albumin (IMA)) as well as progression of liver fibrosis were evaluated.<h4>Results</h4>Compared to SC individuals, those in the CHC group exhibited at baseline higher levels of oxLDL, 8Journal of virus eradication100318https://www.ebi.ac.uk/biostudies/studies/S-EPMC10091014biostudies-literatureReversibility of some oxidative stress markers in chronic hepatitis C patients after receiving direct-acting antiviral agents.PMC10091014Sun HYYoung KCChien SCCheng PNFeng ICChiu HCWang STChiu YCfalseReversibility of some oxidative stress markers in chronic hepatitis C patients after receiving direct-acting antiviral agents.<h4>Introduction</h4>Hepatitis C (HCV) is associated with extra-hepatic involvment, morbidity as well as metabolic changes. Whether these might be reversible if sustained virologic response (SVR) is achieved by direct-acting antiviral (DAA) therapy remains unknown.<h4>Methods</h4>Chronic hepatitis C (CHC) individuals receiving DAA treatment with SVR were compared to those who underwent spontaneous clearance (SC) of HCV infection at the 2-year follow-up. Plasma oxidative stress markers (oxidized low-density lipoprotein (oxLDL), 8-hydroxy-2'-deoxyguanosine (8-OHdG), malondialdehyde (MDA) and ischemia-modified albumin (IMA)) as well as progression of liver fibrosis were evaluated.<h4>Results</h4>Compared to SC individuals, those in the CHC group exhibited at baseline higher levels of oxLDL, 82023-01-01T00:00:00Z2023 Mar2025-04-04T07:35:02.708Z2025-04-04T07:35:02.708ZS-EPMC100910143706543210.1016/j.jve.2023.100318