biostudies-literatureUnknown48(12)Miyamoto T<h4>Aim</h4>Lobular endocervical glandular hyperplasia (LEGH) is a multicystic proliferative disorder of the uterine cervix. The aim of this review was to clarify the current understanding of this unique tumor.<h4>Method</h4>This article reviews the chronological progress of research regarding clinico-pathological and genetic aspects of LEGH and related cervical cystic diseases such as Nabothian cyst and adenocarcinoma of gastric type (GAS), using the literature and data from our institute. We also describe clinical management including preoperative diagnosis and adequate surgical/expectant treatment based on the biological features.<h4>Results</h4>Recent studies revealed several unique aspects of LEGH, that is, (i) production of gastric mucin, (ii) symptomatic and histological similarity The journal of obstetrics and gynaecology research3056-3067https://www.ebi.ac.uk/biostudies/studies/S-EPMC10092153biostudies-literatureBiology and management of lobular endocervical glandular hyperplasia.PMC10092153Miyamoto TKobara HShiozawa TfalseBiology and management of lobular endocervical glandular hyperplasia.<h4>Aim</h4>Lobular endocervical glandular hyperplasia (LEGH) is a multicystic proliferative disorder of the uterine cervix. The aim of this review was to clarify the current understanding of this unique tumor.<h4>Method</h4>This article reviews the chronological progress of research regarding clinico-pathological and genetic aspects of LEGH and related cervical cystic diseases such as Nabothian cyst and adenocarcinoma of gastric type (GAS), using the literature and data from our institute. We also describe clinical management including preoperative diagnosis and adequate surgical/expectant treatment based on the biological features.<h4>Results</h4>Recent studies revealed several unique aspects of LEGH, that is, (i) production of gastric mucin, (ii) symptomatic and histological similarity 2022-01-01T00:00:00Z2022 Dec2025-04-04T14:23:40.424Z2025-04-04T14:23:40.424ZS-EPMC100921533617781010.1111/jog.15441