biostudies-literaturePerez KNINDS NIH HHS2703https://www.ebi.ac.uk/biostudies/studies/S-EPMC10095151biostudies-literatureUnknown12(7)Infections remain a leading cause of neonatal death, especially among the extremely preterm infants. To evaluate the incidence, pathogenesis, and in-hospital outcomes associated with sepsis among hospitalized extremely preterm infants born at 24-0/7 to 27-6/7 weeks of gestation, we designed a post hoc analysis of data collected prospectively during the Preterm Epo Neuroprotection (PENUT) Trial, NCT #01378273. We analyzed culture positive infection data, as well as type and duration of antibiotic course and described their association with in-hospital morbidities and mortality. Of 936 included infants, 229 (24%) had at least one positive blood culture during their hospitalization. Early onset sepsis (EOS, ≤3 days after birth) occurred in 6% of the infants, with Coagulase negative StaphylocoJournal of clinical medicinePatterns of Infections among Extremely Preterm Infants.PMC100951511U01NS077953; 1U01NS077955Wood TRComstock BAJuul SEMayock DEHeagerty PJPerez KPuia-Dumitrescu MOn Behalf Of The Penut ConsortiumfalsePatterns of Infections among Extremely Preterm Infants.Infections remain a leading cause of neonatal death, especially among the extremely preterm infants. To evaluate the incidence, pathogenesis, and in-hospital outcomes associated with sepsis among hospitalized extremely preterm infants born at 24-0/7 to 27-6/7 weeks of gestation, we designed a post hoc analysis of data collected prospectively during the Preterm Epo Neuroprotection (PENUT) Trial, NCT #01378273. We analyzed culture positive infection data, as well as type and duration of antibiotic course and described their association with in-hospital morbidities and mortality. Of 936 included infants, 229 (24%) had at least one positive blood culture during their hospitalization. Early onset sepsis (EOS, ≤3 days after birth) occurred in 6% of the infants, with Coagulase negative Staphyloco2023-01-01T00:00:00Z2023 Apr2025-04-22T05:03:52.697Z2025-04-05T21:10:31.539ZS-EPMC100951513704878610.3390/jcm12072703