biostudies-literatureHuang ZWStartup Fund for scientific research from Fujian Medical Universitye2972https://www.ebi.ac.uk/biostudies/studies/S-EPMC10097049biostudies-literatureUnknown13(4)<h4>Background</h4>Alzheimer's disease (AD) is an irreversible, progressive brain disorder that impairs memory, thinking, language, and, eventually, the ability to carry out the simplest of tasks. Tau protein, the major component of neurofibrillary tangles, is considered a key mediator of AD pathogenesis. The association between obstructive sleep apnea (OSA) and circulating tau remains unclear. The aim of the present meta-analysis was to evaluate the relationship between OSA and circulating tau via quantitative analysis.<h4>Methods</h4>A systematic search of Pubmed, Embase, and Web of Science were performed. The mean values of circulating total tau (T-tau) and phosphorylated tau (P-tau) in OSA and control groups were extracted. Standardized mean difference (SMD) with 95% confidence intervaBrain and behaviorThe relationship between obstructive sleep apnea and circulating tau levels: A meta-analysis.PMC100970492020QH12922020QH1264Huang ZWHuang YFLi HWang TZZeng HXHuang YPLin LHuang WSfalseThe relationship between obstructive sleep apnea and circulating tau levels: A meta-analysis.<h4>Background</h4>Alzheimer's disease (AD) is an irreversible, progressive brain disorder that impairs memory, thinking, language, and, eventually, the ability to carry out the simplest of tasks. Tau protein, the major component of neurofibrillary tangles, is considered a key mediator of AD pathogenesis. The association between obstructive sleep apnea (OSA) and circulating tau remains unclear. The aim of the present meta-analysis was to evaluate the relationship between OSA and circulating tau via quantitative analysis.<h4>Methods</h4>A systematic search of Pubmed, Embase, and Web of Science were performed. The mean values of circulating total tau (T-tau) and phosphorylated tau (P-tau) in OSA and control groups were extracted. Standardized mean difference (SMD) with 95% confidence interva2023-01-01T00:00:00Z2023 Apr2025-04-18T21:19:36.621Z2025-02-18T23:40:30.679ZS-EPMC100970493693883410.1002/brb3.2972