{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(2)"],"submitter":["Al Moosawi M"],"pubmed_abstract":["<h4>Background</h4>The one-stage assay (OSA) and the chromogenic assay (CSA) are 2 factor VIII (FVIII) assays used for the diagnosis and classification of hemophilia A. Discrepancies between the 2 assays exist in approximately one-third of patients with mild hemophilia A.<h4>Objectives</h4>The objectives of this study were to report the proportion of patients with mild or moderate hemophilia A and OSA-CSA discrepancies and to report the observed changes in treatment approach prompted by the presence of assay discrepancy. The study aimed to identify OSA:CSA ratio associated with the highest sensitivity for identification of patients in whom modification of treatment approach may be recommended.<h4>Methods</h4>This is a retrospective cohort study including adult (>18-year-old) patients with "],"journal":["Research and practice in thrombosis and haemostasis"],"pagination":["100098"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10099308"],"repository":["biostudies-literature"],"pubmed_title":["Treatment changes in hemophilia A with chromogenic factor VIII assay implementation."],"pmcid":["PMC10099308"],"pubmed_authors":["Jackson S","Dallas KL","Wong SKW","Nicolson H","Al Moosawi M"],"additional_accession":[]},"is_claimable":false,"name":"Treatment changes in hemophilia A with chromogenic factor VIII assay implementation.","description":"<h4>Background</h4>The one-stage assay (OSA) and the chromogenic assay (CSA) are 2 factor VIII (FVIII) assays used for the diagnosis and classification of hemophilia A. Discrepancies between the 2 assays exist in approximately one-third of patients with mild hemophilia A.<h4>Objectives</h4>The objectives of this study were to report the proportion of patients with mild or moderate hemophilia A and OSA-CSA discrepancies and to report the observed changes in treatment approach prompted by the presence of assay discrepancy. The study aimed to identify OSA:CSA ratio associated with the highest sensitivity for identification of patients in whom modification of treatment approach may be recommended.<h4>Methods</h4>This is a retrospective cohort study including adult (>18-year-old) patients with ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-04T20:17:40.288Z","creation":"2025-04-04T20:17:40.288Z"},"accession":"S-EPMC10099308","cross_references":{"pubmed":["37063773"],"doi":["10.1016/j.rpth.2023.100098"]}}