{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["61(51)"],"submitter":["Couturier C"],"pubmed_abstract":["Herein, we describe the myxobacterial natural product Corramycin isolated from Corallococcus coralloides. The linear peptide structure contains an unprecedented (2R,3S)-γ-N-methyl-β-hydroxy-histidine moiety. Corramycin exhibits anti-Gram-negative activity against Escherichia coli (E. coli) and is taken up via two transporter systems, SbmA and YejABEF. Furthermore, the Corramycin biosynthetic gene cluster (BGC) was identified and a biosynthesis model was proposed involving a 12-modular non-ribosomal peptide synthetase/polyketide synthase. Bioinformatic analysis of the BGC combined with the development of a total synthesis route allowed for the elucidation of the molecule's absolute configuration. Importantly, intravenous administration of 20 mg kg<sup>-1</sup> of Corramycin in an E. coli mo"],"journal":["Angewandte Chemie (International ed. in English)"],"pagination":["e202210747"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10099666"],"repository":["biostudies-literature"],"pubmed_title":["Structure Elucidation, Total Synthesis, Antibacterial In Vivo Efficacy and Biosynthesis Proposal of Myxobacterial Corramycin."],"pmcid":["PMC10099666"],"pubmed_authors":["Vermat T","Bauer A","Cazals V","Schummer D","Muller R","Taillier T","Deckarm S","Couturier C","Dubarry N","Leroi-Geissler C","Sizun P","Rey A","Toti L","Haag Richter S","Renard S","Kurz M","Poverlein C","Harmrolfs K","von Tesmar A","Silve S","Stump H","Wink J","Groß S","Mourez M","Bacque E","Fievet A","Lessoud E","Fraisse L","Versluys S","Hoffmann J","Zaburannyi N","Hoffmann M","Prasad Awal R"],"additional_accession":[]},"is_claimable":false,"name":"Structure Elucidation, Total Synthesis, Antibacterial In Vivo Efficacy and Biosynthesis Proposal of Myxobacterial Corramycin.","description":"Herein, we describe the myxobacterial natural product Corramycin isolated from Corallococcus coralloides. The linear peptide structure contains an unprecedented (2R,3S)-γ-N-methyl-β-hydroxy-histidine moiety. Corramycin exhibits anti-Gram-negative activity against Escherichia coli (E. coli) and is taken up via two transporter systems, SbmA and YejABEF. Furthermore, the Corramycin biosynthetic gene cluster (BGC) was identified and a biosynthesis model was proposed involving a 12-modular non-ribosomal peptide synthetase/polyketide synthase. Bioinformatic analysis of the BGC combined with the development of a total synthesis route allowed for the elucidation of the molecule's absolute configuration. Importantly, intravenous administration of 20 mg kg<sup>-1</sup> of Corramycin in an E. coli mo","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-05T12:13:16.062Z","creation":"2025-04-05T12:13:16.062Z"},"accession":"S-EPMC10099666","cross_references":{"pubmed":["36197755"],"doi":["10.1002/anie.202210747"]}}