{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Haack PA"],"funding":["Deutsche Forschungsgemeinschaft"],"pagination":["e202212946"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10100342"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["61(52)"],"pubmed_abstract":["During our search for novel myxobacterial natural products, we discovered the thiamyxins: thiazole- and thiazoline-rich non-ribosomal peptide-polyketide hybrids with potent antiviral activity. We isolated four congeners of this unprecedented natural product family with the non-cyclized thiamyxin D fused to a glycerol unit at the C-terminus. Alongside their structure elucidation, we present a concise biosynthesis model based on biosynthetic gene cluster analysis and isotopically labelled precursor feeding. We report incorporation of a 2-(hydroxymethyl)-4-methylpent-3-enoic acid moiety by a GCN5-related N-acetyltransferase-like decarboxylase domain featuring polyketide synthase. The thiamyxins show potent inhibition of RNA viruses in cell culture models of corona, zika and dengue virus infec"],"journal":["Angewandte Chemie (International ed. in English)"],"pubmed_title":["Thiamyxins: Structure and Biosynthesis of Myxobacterial RNA-Virus Inhibitors."],"pmcid":["PMC10100342"],"funding_grant_id":["EXC 2155 - project number 390874280"],"pubmed_authors":["Voltz A","Harmrolfs K","Haid S","Popoff A","Kim H","Gunesch AP","Muller R","Garcia R","Haack PA","Bader CD","Pietschmann T","Bartenschlager R"],"additional_accession":[]},"is_claimable":false,"name":"Thiamyxins: Structure and Biosynthesis of Myxobacterial RNA-Virus Inhibitors.","description":"During our search for novel myxobacterial natural products, we discovered the thiamyxins: thiazole- and thiazoline-rich non-ribosomal peptide-polyketide hybrids with potent antiviral activity. We isolated four congeners of this unprecedented natural product family with the non-cyclized thiamyxin D fused to a glycerol unit at the C-terminus. Alongside their structure elucidation, we present a concise biosynthesis model based on biosynthetic gene cluster analysis and isotopically labelled precursor feeding. We report incorporation of a 2-(hydroxymethyl)-4-methylpent-3-enoic acid moiety by a GCN5-related N-acetyltransferase-like decarboxylase domain featuring polyketide synthase. The thiamyxins show potent inhibition of RNA viruses in cell culture models of corona, zika and dengue virus infec","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-06-05T06:48:33.495Z","creation":"2025-02-18T23:40:43.347Z"},"accession":"S-EPMC10100342","cross_references":{"pubmed":["36208117"],"doi":["10.1002/anie.202212946"]}}