{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Gardinassi LG"],"funding":["Conselho Nacional de Desenvolvimento Científico e Tecnológico","Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","amfAR, The Foundation for AIDS Research","Fundação de Amparo à Pesquisa do Estado de Goiás","Instituto Serrapilheira"],"pubmed_abstract":["Severe manifestations of coronavirus disease 2019 (COVID-19) and mortality have been associated with physiological alterations that provide insights into the pathogenesis of the disease. Moreover, factors that drive recovery from COVID-19 can be explored to identify correlates of protection. The cellular metabolism represents a potential target to improve survival upon severe disease, but the associations between the metabolism and the inflammatory response during COVID-19 are not well defined. We analyzed blood laboratorial parameters, cytokines, and metabolomes of 150 individuals with mild to severe disease, of which 33 progressed to a fatal outcome. A subset of 20 individuals was followed up after hospital discharge and recovery from acute disease. We used hierarchical community network"],"journal":["Microbiology spectrum"],"pagination":["e0219422"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10100880"],"repository":["biostudies-literature"],"pubmed_title":["Integrated Metabolic and Inflammatory Signatures Associated with Severity of, Fatality of, and Recovery from COVID-19."],"pmcid":["PMC10100880"],"funding_grant_id":["110027-67-RGRL","R-2011-37433","202010267000284"],"pubmed_authors":["de Araujo GL","Silva JMM","Meira S","da Silva LC","Guilarde AO","Lima GDS","Coelho V","Spadafora Ferreira M","Chaves AR","Romao PRT","Fonseca SG","Gardinassi LG","Rodrigues MF","Dos Santos GF","Masson LC","Borges MASB","Moraes BGN","Dos Anjos DCC","Gomes Junior AR","Simas RC","de Souza FP","Souza M","Vaz BG","Servian CDP","da Silva RR","Fiaccadori FS"],"additional_accession":[]},"is_claimable":false,"name":"Integrated Metabolic and Inflammatory Signatures Associated with Severity of, Fatality of, and Recovery from COVID-19.","description":"Severe manifestations of coronavirus disease 2019 (COVID-19) and mortality have been associated with physiological alterations that provide insights into the pathogenesis of the disease. Moreover, factors that drive recovery from COVID-19 can be explored to identify correlates of protection. The cellular metabolism represents a potential target to improve survival upon severe disease, but the associations between the metabolism and the inflammatory response during COVID-19 are not well defined. We analyzed blood laboratorial parameters, cytokines, and metabolomes of 150 individuals with mild to severe disease, of which 33 progressed to a fatal outcome. A subset of 20 individuals was followed up after hospital discharge and recovery from acute disease. We used hierarchical community network","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-05-28T11:48:54.257Z","creation":"2025-04-07T03:18:43.459Z"},"accession":"S-EPMC10100880","cross_references":{"pubmed":["36852984"],"doi":["10.1128/spectrum.02194-22"]}}