biostudies-literatureUnknownGardinassi LGConselho Nacional de Desenvolvimento Científico e TecnológicoCoordenação de Aperfeiçoamento de Pessoal de Nível SuperioramfAR, The Foundation for AIDS ResearchFundação de Amparo à Pesquisa do Estado de GoiásInstituto SerrapilheiraSevere manifestations of coronavirus disease 2019 (COVID-19) and mortality have been associated with physiological alterations that provide insights into the pathogenesis of the disease. Moreover, factors that drive recovery from COVID-19 can be explored to identify correlates of protection. The cellular metabolism represents a potential target to improve survival upon severe disease, but the associations between the metabolism and the inflammatory response during COVID-19 are not well defined. We analyzed blood laboratorial parameters, cytokines, and metabolomes of 150 individuals with mild to severe disease, of which 33 progressed to a fatal outcome. A subset of 20 individuals was followed up after hospital discharge and recovery from acute disease. We used hierarchical community networkMicrobiology spectrume0219422https://www.ebi.ac.uk/biostudies/studies/S-EPMC10100880biostudies-literatureIntegrated Metabolic and Inflammatory Signatures Associated with Severity of, Fatality of, and Recovery from COVID-19.PMC10100880110027-67-RGRLR-2011-37433202010267000284de Araujo GLSilva JMMMeira Sda Silva LCGuilarde AOLima GDSCoelho VSpadafora Ferreira MChaves ARRomao PRTFonseca SGGardinassi LGRodrigues MFDos Santos GFMasson LCBorges MASBMoraes BGNDos Anjos DCCGomes Junior ARSimas RCde Souza FPSouza MVaz BGServian CDPda Silva RRFiaccadori FSfalseIntegrated Metabolic and Inflammatory Signatures Associated with Severity of, Fatality of, and Recovery from COVID-19.Severe manifestations of coronavirus disease 2019 (COVID-19) and mortality have been associated with physiological alterations that provide insights into the pathogenesis of the disease. Moreover, factors that drive recovery from COVID-19 can be explored to identify correlates of protection. The cellular metabolism represents a potential target to improve survival upon severe disease, but the associations between the metabolism and the inflammatory response during COVID-19 are not well defined. We analyzed blood laboratorial parameters, cytokines, and metabolomes of 150 individuals with mild to severe disease, of which 33 progressed to a fatal outcome. A subset of 20 individuals was followed up after hospital discharge and recovery from acute disease. We used hierarchical community network2023-01-01T00:00:00Z2023 Feb2026-05-28T11:48:54.257Z2025-04-07T03:18:43.459ZS-EPMC101008803685298410.1128/spectrum.02194-22