biostudies-literatureUnknownHe TNational Natural Science Foundation of ChinaNational Agricultural Product Quality and Safety Risk AssessmentNatural Science Foundation of Jiangsu ProvinceWith the issue of the antimicrobial additive ban in feed in Chinese animal husbandry, it is important to determine the potential drivers of the spread of the newly discovered tigecycline-resistant <i>tet</i>(X)-variant genes. Here, we investigated the correlations between residues of heavy metals, antimicrobials, and pesticides and the relative abundance of <i>tet</i>(X)-variant genes in 94 commercial organic-fertilizer samples collected from 9 Chinese provinces. A total of 5 heavy metals (mercury, lead, arsenic, chromium, and cadmium), 10 antimicrobials, and 18 pesticides were detected. The <i>tet</i>(X)-variant genes, including <i>tet</i>(X)/(X2), <i>tet</i>(X3), <i>tet</i>(X4), <i>tet</i>(X5), and <i>tet</i>(X6) were detected in 39 (41.5%) samples. Although <i>tet</i>(X)-variant-carryinMicrobiology spectrume0425122https://www.ebi.ac.uk/biostudies/studies/S-EPMC10100909biostudies-literatureComprehensive Analysis of Antimicrobial, Heavy Metal, and Pesticide Residues in Commercial Organic Fertilizers and Their Correlation with Tigecycline-Resistant <i>tet</i>(X)-Variant Genes.PMC10100909BK201902613210272881861138051BK20200056GJFP2021030331930110Luan FTang MHe TLi JJi XWei RWang RZhu LGong LLi RWang YfalseComprehensive Analysis of Antimicrobial, Heavy Metal, and Pesticide Residues in Commercial Organic Fertilizers and Their Correlation with Tigecycline-Resistant <i>tet</i>(X)-Variant Genes.With the issue of the antimicrobial additive ban in feed in Chinese animal husbandry, it is important to determine the potential drivers of the spread of the newly discovered tigecycline-resistant <i>tet</i>(X)-variant genes. Here, we investigated the correlations between residues of heavy metals, antimicrobials, and pesticides and the relative abundance of <i>tet</i>(X)-variant genes in 94 commercial organic-fertilizer samples collected from 9 Chinese provinces. A total of 5 heavy metals (mercury, lead, arsenic, chromium, and cadmium), 10 antimicrobials, and 18 pesticides were detected. The <i>tet</i>(X)-variant genes, including <i>tet</i>(X)/(X2), <i>tet</i>(X3), <i>tet</i>(X4), <i>tet</i>(X5), and <i>tet</i>(X6) were detected in 39 (41.5%) samples. Although <i>tet</i>(X)-variant-carryin2023-01-01T00:00:00Z2023 Mar2026-06-13T06:10:26.738Z2024-11-21T01:59:04.682ZS-EPMC101009093691699410.1128/spectrum.04251-22