biostudies-literatureHu JNational Natural Science Foundation of China1143590https://www.ebi.ac.uk/biostudies/studies/S-EPMC10100928biostudies-literatureUnknown14<h4>Background</h4>The potential role of neprilysin (NEP) in glucose metabolism has been found by basic studies but lacks population evidence. The objective of this study was to examine the association between serum NEP and diabetes in Chinese adults.<h4>Methods</h4>In a prospective longitudinal cohort study - the Gusu cohort (n=2,286, mean age: 52 years, 61.5% females), the cross-sectional, longitudinal, and prospective associations between serum NEP and diabetes were systemically examined by logistic regression adjusting for conventional risk factors. Serum NEP was measured at baseline using commercial ELISA assays. Fasting glucose was repeatedly measured 4 years apart.<h4>Results</h4>The cross-sectional analysis found a positive association between serum NEP and fasting glucose at baselFrontiers in endocrinologyAssociation between soluble neprilysin and diabetes: Findings from a prospective longitudinal study.PMC1010092882173596, 81903384, 81872690Peng HLiu YHu JLu YChen LZhu HZhang MJiang TDai YZhu SfalseAssociation between soluble neprilysin and diabetes: Findings from a prospective longitudinal study.<h4>Background</h4>The potential role of neprilysin (NEP) in glucose metabolism has been found by basic studies but lacks population evidence. The objective of this study was to examine the association between serum NEP and diabetes in Chinese adults.<h4>Methods</h4>In a prospective longitudinal cohort study - the Gusu cohort (n=2,286, mean age: 52 years, 61.5% females), the cross-sectional, longitudinal, and prospective associations between serum NEP and diabetes were systemically examined by logistic regression adjusting for conventional risk factors. Serum NEP was measured at baseline using commercial ELISA assays. Fasting glucose was repeatedly measured 4 years apart.<h4>Results</h4>The cross-sectional analysis found a positive association between serum NEP and fasting glucose at basel2023-01-01T00:00:00Z20232025-04-18T14:23:30.273Z2025-04-07T00:30:27.844ZS-EPMC101009283706576410.3389/fendo.2023.1143590