biostudies-literatureUnknown102(15)Huang Y<h4>Background</h4>Lymphovascular space invasion (LVSI) is a prognostic factor in the existing TNM classification system. The present meta-analysis assessed the role of LVSI in predicting the prognosis of stage IA to IIB cervical cancer (CC).<h4>Materials and methods</h4>PubMed, EMBASE, and Cochrane Library electronic databases were searched to determine relevant articles published in the English language. Our search deadline was May 2022. Critical Appraisal of Prognostic Studies was used to assess the quality for each article. Pooled hazard ratios (HRs) were used to evaluate the performance of LVSI in prognosis prediction.<h4>Results</h4>We enrolled 8 studies involving 25,352 patients published after 2010. Thus, high LVSI was an unfavorable factor in predicting overall survival (HR, 2.08;Medicinee33547https://www.ebi.ac.uk/biostudies/studies/S-EPMC10101290biostudies-literaturePrognostic value of lymphovascular space invasion in stage IA to IIB cervical cancer: A meta-analysis.PMC10101290Li XHuang YLiu LXu DWen WfalsePrognostic value of lymphovascular space invasion in stage IA to IIB cervical cancer: A meta-analysis.<h4>Background</h4>Lymphovascular space invasion (LVSI) is a prognostic factor in the existing TNM classification system. The present meta-analysis assessed the role of LVSI in predicting the prognosis of stage IA to IIB cervical cancer (CC).<h4>Materials and methods</h4>PubMed, EMBASE, and Cochrane Library electronic databases were searched to determine relevant articles published in the English language. Our search deadline was May 2022. Critical Appraisal of Prognostic Studies was used to assess the quality for each article. Pooled hazard ratios (HRs) were used to evaluate the performance of LVSI in prognosis prediction.<h4>Results</h4>We enrolled 8 studies involving 25,352 patients published after 2010. Thus, high LVSI was an unfavorable factor in predicting overall survival (HR, 2.08;2023-01-01T00:00:00Z2023 Apr2025-07-10T03:08:13.14Z2025-02-18T23:40:10.941ZS-EPMC101012903705804510.1097/MD.0000000000033547